grant
Structure And Computationally-guided Design Of Enzymes Targeting Antibody Glycosylation
Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
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Description preview
The immune effector functions of IgG antibodies can be fine-tuned by modification of conserved moieties, called N-linked glycans, within their Fc region. Antibody glycoengineering is of considerable biotechnological interest and has been utilised in several clinically approved antibodies, such as the cancer therapeutic Mogamulizumab (generated…
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