grant
WNT Signaling in the Pathogenesis of Atrial Fibrillation
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AT-binding transcription factor 1ATAC sequencingATAC-seqATACseqATBF1AddressAdverse effectsAdvisory CommitteesAffectApoplexyArrhythmiaAssayAssay for Transposase-Accessible Chromatin using sequencingAtrialAtrial FibrillationAuricular FibrillationAutomobile DrivingAwardBasal Transcription FactorBasal transcription factor genesBioassayBiochemicalBiologicalBiological AssayBlood SerumBody TissuesBrain Vascular AccidentCLP modelCLP mouse modelCaM KIICaM PK IICaM kinase IICaMKIICalciumCardiacCardiac ArrhythmiaCardiac AtriumCardiac Electrophysiologic TechniquesCardiac Electrophysiological DiagnosticsCardiac Muscle CellsCardiac MyocytesCardiac developmentCardiocyteCardiologyCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCecal ligation perforationCell BodyCell Communication and SignalingCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeClinicalComplex thinkingCritical ThinkingDataData AnalysesData AnalysisDeathDedicationsDevelopmentDysfunctionElectrophysiologyElectrophysiology (science)EnhancersEvaluative ThinkingFacultyFibroblastsFibrosisFunctional disorderFutureGWA studyGWASGene TranscriptionGene variantGeneral HospitalsGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGenetic studyGerm LinesGlucocorticoidsGoalsHeartHeart ArrhythmiasHeart AtriumHeart Muscle CellsHeart VascularHeart failureHeart myocyteHumanHypertensionImmuneImmunesInflammationIntracellular Communication and SignalingInvestigatorsKinasesLinkMAP kinaseMassachusettsMediatingMentorsMentorshipMiceMice MammalsMitogen-Activated Protein KinasesModelingModern ManMorbidityMorbidity - disease rateMurineMusNa elementNeurophysiology / ElectrophysiologyNuclear RNAObesityPathogenesisPathologicPathologyPathway interactionsPhenotypePhosphotransferase GenePhosphotransferasesPhysiciansPhysiologyPhysiopathologyPopulationPredispositionPrevalencePublic HealthPublicationsRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinReproducibilityResearchResearch PersonnelResearchersRiskRisk FactorsRisk-associated variantRoleScientific PublicationScientistSepsisSerumSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSodiumStressStrokeSusceptibilityTask ForcesTechnical ExpertiseTherapeuticTherapeutic InterventionTimeTissuesTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransphosphorylasesUpregulationVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderVentricular ArrhythmiaWNT Signaling PathwayWNT signalingWorkZFHX3ZFHX3 geneadiposityadvisory teamallelic variantassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingassociate facultyassociate professorbiologicbiological signal transductionbrain attackcalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcardiac electrophysiologycardiac failurecardiogenesiscardiomyocytecardiovascular effectscecal ligation and perforationcecal ligation and puncturececal ligation puncturececum ligation and puncturececum ligation puncturecell typecerebral vascular accidentcerebrovascular accidentcirculatory systemcorpulencedata interpretationdetermine efficacydevelopmentaldrivingeconomic costefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy studyelectrophysiologicalevaluate efficacyexamine efficacyexperiencefetalgenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic datagenomic datasetgenomic variantglobal gene expressionglobal transcription profileheart developmentheart electrophysiologyheart formationhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderinterestintervention therapymedical collegemedical schoolsmembermid-career facultymidcareer facultymortalitymouse modelmultiomicsmultiple omicsmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpanomicspathophysiologypathwayreceptorrisk allelerisk generisk genotyperisk locirisk locusrisk variantschool of medicineskillssocial rolestemstrokedstrokestechnical skillstherapeutic agent developmenttherapeutic developmenttherapeutic targettranscription factortranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicswhole genome association analysiswhole genome association studyzinc finger homeobox 3
Description preview
Project Summary / Abstract
Atrial fibrillation (AF) is a common sustained cardiac arrhythmia with associated risks that include stroke, heart
failure, and death. Despite the public health burden, our understanding of the pathophysiologic basis of AF
remains incomplete, and this is reflected in the lack of therapeutic advancement. This proposal…
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