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Within-person dynamics of cognition and personality in healthy aging and Alzheimer's disease.
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Apr 2021Deadline 30 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAchievementAchievement AttainmentAdultAdult HumanAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease riskAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid SubstanceAttentionBayesian ModelingBayesian adaptive designsBayesian adaptive modelsBayesian belief networkBayesian belief updating modelBayesian frameworkBayesian hierarchical modelBayesian network modelBayesian nonparametric modelsBayesian spatial data modelBayesian spatial image modelsBayesian spatial modelsBayesian statistical modelsBayesian tracking algorithmsBiologicalClinicalClinical EvaluationClinical TestingClinical TrialsClinical assessmentsCognitionCognition DisordersCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalData SetDementiaDiseaseDisease ProgressionDisorderDisturbance in cognitionEncapsulatedEquationEvaluationGoalsImpaired cognitionImpairmentIndividualInternationalInterventionIntervention StudiesMRI biomarkerMRI markerMT-bound tauMeasurementMeasuresMentorsMinorModelingMoodsMotivationNerve DegenerationNeuron DegenerationNoiseOlder PopulationOutcomePETPET ScanPET imagingPETSCANPETTPerformancePersonalityPersonality AssessmentPersonsPhenotypePlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredicting RiskPrevention trialPrimary Senile Degenerative DementiaProbabilistic ModelsProbability ModelsProcessRad.-PETResearchResearch DesignResearch TechnicsResearch TechniquesSecondary PreventionSeveritiesStatistical ModelsStimulusStudy TypeTechniquesTestingTimeTrainingValidationVariantVariationadult youthadulthoodadvanced analyticsalzheimer riskanalyzing longitudinalattentional controlbehavior predictionbehavioral predictionbiologiccareer developmentclinical testcognitive assessmentcognitive changecognitive diseasecognitive disordercognitive dysfunctioncognitive functioncognitive losscognitive performancecognitive processcognitive syndromecognitive testingcohortcomputer based predictiondesigndesigningdisease phenotypedrug efficacyexperienceforecasting riskhealthy aginghealthy human agingimprovedin vivoinnovateinnovationinnovativeinsightintervention effectintervention researchinterventional researchinterventional studyinterventions researchlate in lifelate lifelongitudinal analysislongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designmagnetic resonance imaging biomarkermagnetic resonance imaging markermicrotubule bound taumicrotubule-bound tauneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnovelolder adultolder adulthoodolder groupsolder individualsolder personpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpreclinicalpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive modelingpredictive riskpredicts riskprimary degenerative dementiapsychologicpsychologicalresearch clinical testingrisk predictionrisk predictionssenile dementia of the Alzheimer typestatistical linear mixed modelsstatistical linear modelsstudy designtautau Proteinstau factorvalidationsyoung adultyoung adult ageyoung adulthoodτ Proteins
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Project Abstract / Summary
Intervention studies of Alzheimer disease (AD) require accurate measurement of cognitive function across
many years. Adequate description of function is hampered by the fact that cognition can significantly fluctuate
from moment-to-moment and from day-to-day. This additional variance adds measurement noise which
impairs…
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