grant
Wisconsin longitudinal study: Initial lifetime's impact on Alzheimer's disease and related disorders (WLS-ILIAD)
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Sept 2018Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD diagnosticAD pathologyAD related dementiaADRDActive Follow-upAddressAfrican AmericanAfro AmericanAfroamericanAgeAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's diagnosticAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease diagnosticAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid SubstanceAttentionBackBehavioralBiologic SciencesBiologicalBiological MarkersBiological SciencesBioscienceBirthBlackBlack raceBloodBlood PlasmaBlood Reticuloendothelial SystemBrain scanCensusesCerebrospinal FluidClinicClinicalCognitionCognitiveCohort StudiesCollectionCommunitiesConcurrent StudiesDataData SetDementiaDiseaseDisorderDorsumEconomicsEducationEducational aspectsEmploymentEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationExposure toFundingGenderGoalsGrantHealthHealth CareIndigenousIndividualLifeLife CycleLife Cycle StagesLife SciencesLinkLong-Term CareLong-term cohort studyLongitudinal StudiesLongitudinal cohort studyMT-bound tauMeasuresMedicalNational Institutes of HealthNaturePETPET ScanPET imagingPETSCANPETTParticipantParturitionPathologyPersonsPlasmaPlasma SerumPopulation StudyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessProtocolProtocols documentationRaceRacesRacial GroupRad.-PETRandom AllocationRandom SelectionRecordsResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskSamplingSampling StudiesShapesSocial ConditionsSocial SciencesSocial supportSocietal ConditionsSymptomsUnited States National Institutes of HealthVariantVariationVisitWisconsinWomanWorkactive followupagesalzheimer riskbasebasesbehavioral healthbio-markersbiologicbiologic markerbiomarkerblood-based biomarkerblood-based markercare givingcaregivingcerebral spinal fluidcognitive functioncohortcostdementia riskdifferences due to racedifferences in racediffers by racediffers in raceeconomicethnic differenceethnic diversityethnic subgroupethnically diverseethnicity differenceethnicity groupexposomeextended carefamily supportfollow upfollow-upfollowed upfollowupgender differencegender-associated differenceglobal healthinattentioninattentivenessinsightlife courselong-term studylongitudinal outcome studiesmenmicrotubule bound taumicrotubule-bound taunovelolder adultolder adulthoodparticipant enrollmentpatient enrollmentphysical conditioningphysical healthpopulation-based studypopulation-level studypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprimary degenerative dementiaprospectiverace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial diversityracial originracial populationracial subgroupracially differentracially diverseresilienceresilientresponserisk factor for dementiarisk for dementiasenile dementia of the Alzheimer typesexsocialsocial health determinantssocial relationshipssocial support networksocio-economicsocio-economicallysocioeconomicallysocioeconomicsspinal fluidstudies of populationsstudy of the populationtautau Proteinstau factorτ Proteins
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Abstract
The overarching scientific premise of this application is to evaluate how the accumulation of social advantage
and adversity over the full life course impacts risk and resilience against Alzheimer’s Disease (AD) and Related
Dementias (ADRD). While there is considerable enthusiasm across the social and biological sciences
regarding the…
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