grant
Whole Genome and Whole Exome Sequencing to Identify Genes for Type 2 Diabetes and Obesity
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old1,2,3-Propanetriol1,2,3-Trihydroxypropane21+ years oldAcylcholesterol LipaseAdipocytesAdipose CellAdipose tissueAdultAdult HumanAdult-Onset Diabetes MellitusAffectAllelesAllelomorphsAmerican IndianAmishAnimalsArchitectureArizonaAsian ancestryAsian descentBMIBMI percentileBMI z-scoreBlood PlasmaBody mass indexButyratesCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell SignalingCell SizeCellsChildChild YouthChildren (0-21)Cholesterol Ester HydrolaseCholesterol EsteraseCholesteryl Oleate HydrolaseCholesterylester HydrolaseCodeCoding SystemCodonCodon NucleotidesComplexD-Amino Acid DehydrogenaseD-Amino-Acid OxidaseD-GlucoseDNA SequenceDNA analysisDataDevelopmentDextroseDiabetic Kidney DiseaseDiabetic NephropathyDiseaseDisorderDopamineDunnigan Familial Partial Lipodystrophy Dunnigan SyndromeDunnigan SyndromeDyslipidemiasEast AsianElementsEnergy ExpenditureEnergy MetabolismEngineering / ArchitectureEnzyme GeneEnzymesEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEuropeanEuropean ancestryExclusionExhibitsExonsFKHRFOXO1FOXO1AFOXO1A geneFamilial partial lipodystrophyFat CellsFatty AcidsFatty LiverFatty TissueForkhead Box O1AForkhead in RhabdomyosarcomaFree Fatty AcidsFrequenciesGWA studyGWASGene FrequencyGene TranscriptionGenesGenetic TranscriptionGenetic studyGenomeGenomicsGenotypeGlucoseGlycerinGlycerolHG38HeritabilityHormone-Sensitive LipaseHourHumanHuman GeneticsHumulin RHydrolysisHydroxytyramineIBP4IGF-1IGF-Binding ProteinsIGF-IIGF-I-SmCIGFBPIGFBP4IGFBP4 geneImpairmentIn VitroIndigenousIndigenous AmericanIndividualInfusionInfusion proceduresInsulinInsulin ResistanceInsulin-Like Growth Factor 1Insulin-Like Growth Factor IInsulin-Like Growth FactorsInsulin-Like Growth-Factor-Binding ProteinsInsulin-Like Somatomedin Peptide IIntracellular Communication and SignalingInvestigatorsIsoformsIsoprenalineIsopropyl NoradrenalineIsopropylarterenolIsopropylnoradrenalineIsopropylnorepinephrineIsoproterenolIsuprelKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceKoberling-Dunnigan SyndromeL-SerineL-ThreonineLGR5LGR5 geneLarge-Scale SequencingLeadLinkLipaseLipidsLipocytesLipoidal Steroid EsteraseLipolysisLiver SteatosisMapsMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMeasuresMediatingMetabolic Protein DegradationMethodsMiceMice MammalsMinorModelingModern ManMurineMusNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonesterified Fatty AcidsNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNonsense CodonNovolin RNuclearNull MouseOGTTObesityOral Glucose Tolerance TestPI-3K/AKTPI3K/AKTPathway interactionsPb elementPersonsPhasePhenotypePlasmaPlasma SerumPopulationPositionPositioning AttributePrediabetesPrediabetes syndromePrediabetic StatePredispositionPremature Stop CodonPrivatizationProtein IsoformsProtein TurnoverProteinsQuetelet indexRNA ExpressionRegular InsulinRegulator GenesRegulatory Protein DegradationReporterReportingResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRoleSamplingSequence AlignmentSerineSiblingsSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSleepSlow-Onset Diabetes MellitusSomatomedin CSomatomedin-Binding ProteinsSomatomedinsStable Diabetes MellitusSteroid Hormone EsteraseSterol Ester AcylhydrolaseSteryl-ester acylhydrolaseSulfation FactorSusceptibilityT2 DMT2DT2DMTechniquesTechnologyTestingThreonineTranscriptionTranscriptional Regulatory ElementsTriacylglycerolTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriglyceridesTriolean HydrolaseType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnderrepresented GroupsUnderrepresented PopulationsUnited StatesVariantVariationadipogenesisadiposeadiposityadult onset diabetesadulthoodallelic frequencyanalyze DNAbiological signal transductioncholesteryl ester synthaseclinical phenotypecorpulencedetection assaydevelopmentaldextro-Amino Acid Oxidasediabetes geneticsdiabetes mellitus geneticsdiabetes riskdisease causing variantdisease riskdisease-causing alleledisease-causing mutationdisorder riskenergy balanceentire genomeenzyme activityethnic subgroupethnicity groupexomeexome sequencingexome-seqfat metabolismfull genomegenetic trans acting elementgenome scalegenome sequencinggenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studyheavy metal Pbheavy metal leadhepatic steatosishepatosteatosisindelinfusionsinsertion/deletioninsertion/deletion mutationinsulin resistantinsulin sensitivityinsulin toleranceinsulinlike growth factorinsulinlike growth factor binding proteinketosis resistant diabeteskidslipid biosynthesislipid metabolismlipogenesislong read seqlong-read sequencinglong-read transcript sequencingloss of functionloss of function mutationlow-frequency mutationmaturity onset diabetesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-synonymous mutationnonsynonymous mutationnonsynonymous single nucleotide polymorphismnonsynonymous single nucleotide variantnonsynonymous single-nucleotide substitutionnonsynonymous variantnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoxidationpathogenic allelepathogenic variantpathwaypre-diabetespre-diabeticprediabeticprotein degradationrare allelerare mutationrare variantreference assemblyreference genomeregulatory genesequencing alignmentsingle nucleotide variantsocial rolesterol esterasetraittrans acting elementtributyrasetriterpenol esterasetype 2 DMtype II DMtype two diabetesunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplewhite adipose tissuewhole genomewhole genome association analysiswhole genome association studyyellow adipose tissueyoungster
Description preview
Indigenous people living in the United States have disproportionate rates of T2D, diabetic nephropathy and obesity, yet large-scale sequencing efforts to identify disease loci have not included individuals from this ethnic group. Therefore, variants that are unique or enriched in specific Indigenous groups, which may identify new therapeutic…
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