grant
What determines the location of meiotic crossovers in the mammalian genome?
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AffectAfricanAllelesAllelomorphsAssayBindingBinding SitesBioassayBiochemistryBiological AssayBiological ChemistryCPD6CRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCYP 2D6CYP2DCYP2D6CYP2D6 geneCYP2DL1CYPIID6Cas nuclease technologyCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsChIP SequencingChIP-seqChIPseqChromatinChromosomal OrganizationChromosomal StructureChromosome OrganizationChromosome StructuresChromosomesClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsCombining SiteComplexConsensusCrossing OverCytochrome P-450 CYP2D6Cytochrome P450 2D6Cytochrome P450 Subfamily IID Polypeptide 6DNA Molecular BiologyDNA RecombinationDNA ReplicationDNA Replication InitiationDNA SynthesisDNA biosynthesisDNA crossoverDNA seqDNA sequencingDNAseqDebrisoquine 4-HydroxylaseDebrisoquine 4-MonooxygenaseDebrisoquine HydroxylaseDetectionDevelopmentDifferences between sexesDiffers between sexesDistantDrug PrescribingDrug PrescriptionsEC 2.1.1ElementsEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEukaryotaEukaryoteExhibitsFoundationsGender BiasGenesGenetic Crossing OverGenetic DeterminismGenetic PredispositionGenetic Predisposition to DiseaseGenetic RecombinationGenetic SusceptibilityGenetic propensityGenomeGoalsHealth SciencesHeterozygoteHi-CHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHumanImipramine 2-HydroxylaseIn SituIndividualInherited PredispositionInherited SusceptibilityIntracellular Communication and SignalingLaboratoriesLibrariesLinkLocationMSH4MSH4 geneMammaliaMammalsMapsMeiosisMeiotic Prophase IMeiotic RecombinationMethodsMethylationMethyltransferaseMiceMice MammalsMitoticModelingModern ManMolecular BiologyMolecular InteractionMurineMusMutS Homolog 4NatureNucleosomesNucleotidesNucleusOrganismP450-2D6P450-DB1P450C2DP450DB1PatternPlayPopulationPositionPositioning AttributePreparationProceduresProcessProphase IProteinsPseudogenesReactive SiteRecombinationRegulatory ElementReplication InitiationReplication OriginResolutionRoleS PeriodS phaseSS DNA BPScienceSex BiasSex DifferencesSexual differencesShapesSignal TransductionSignal Transduction SystemsSignalingSingle-Stranded DNASingle-Stranded DNA-Binding ProteinSiteSortingSparteine MonooxygenaseSpecificitySpermatocytesSpermatogenesisSpermatogoniaSpermatophoresSpermiocytesStructureSubfamily IID Cytochrome P450Subfamily IID-Like 1 Cytochrome P450Synthesis PeriodSynthesis PhaseSystemTechnologyTesticlesTestisTimeTranscription Initiation SiteTranscription Start SiteTranscriptional ControlTranscriptional RegulationUniversity Health ServicesVariantVariationbasebasesbiological signal transductionchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcohesincrossover recombinationdensitydevelopmentalepigeneticallyfunctional genomicsgenetic determinantgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgenome scalegenome-widegenomewidegenomic crossoverheterozygosityhuman malehuman population geneticsin silicoinsightinter-homolog crossoverinterestliving systemlong read seqlong-read sequencinglong-read transcript sequencingmalemale germ cellsmammalian genomemedication prescriptionmeioticmeiotic crossovermethylasenon-sister chromatid exchangenonsister chromatid exchangenovelori Regionpreferencepreparationsprescribed medicationpromoterpromotorresolutionssex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolespermatogonespermatosporespermigoniumspermosporessDNAtelomeretemporal measurementtemporal resolutiontime measurementtransmethylase♂
Description preview
In the last few years we have been able to generate a genome-wide map for hotspots for double-strand breaks in mouse meiosis by using Illumina ChIP-Seq for Dmc1 and Rad51 foci, both of which mark these sites (all in collaboration with the laboratory of Galina Petukhova at the Department of Biochemistry and Molecular Biology at the Uniformed…
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