grant

Visualization of native chromatin-associated complexes to elucidate chromatin regulatory mechanisms

Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 15 Feb 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DActive Follow-upAddressAssayBindingBioassayBiochemicalBiologicalBiological AssayBiological FunctionBiological ProcessCell CycleCell Cycle ProgressionCell DifferentiationCell Differentiation processCell Division CycleChemicalsChromatinChromatin AssemblyChromatin ModelingChromosomesComplexCryo-electron MicroscopyCryoelectron MicroscopyDNADNA Damage RepairDNA RepairDeoxyribonucleic AcidDevelopmentDiseaseDisorderElectron CryomicroscopyFoundationsGene ExpressionGene TranscriptionGenetic TranscriptionGoalsIn VitroKnowledgeMaintenanceMethodologyMethodsModificationMolecular InteractionNucleosomesPhysiologicPhysiologicalPlayProcessProteinsRNA ExpressionRNA and protein interactionRNA-Protein InteractionRegulationResearchRoleStimulusStructureSystemTelomeraseTranscriptionUnscheduled DNA SynthesisVisualizationXenopusXenopus sp.active followupbiologiccellular differentiationchromatin modificationchromatin proteinclawed frogcryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaleggexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgenome integritygenomic integrityinsightnovelreconstitutereconstitutionresponsesocial roletelomerethree dimensional
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Project Summary
Chromatin organizes into distinct functional domains and regulates a wide range of biological processes,

including gene expression, genome integrity maintenance, and DNA accessibility. Chromatin dynamically

adapts its functional states by altering protein composition or introducing chemical modifications in response to

various…

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Visualization of native chromatin-associated complexes to elucidate chromatin regulatory mechanisms — FRED HUTCHINSON CA | Dev Procure