grant
Vibegron: A Novel Treatment for Multisystem Functional Decline in Aging and Obesity
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AD dementiaAccelerationAdipose tissueAdrenergic AgonistsAdrenergic ReceptorAdrenergic Receptor AgonistAdrenoceptorsAdrenomimeticsAdult-Onset Diabetes MellitusAgingAgonistAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnthropometryBioenergeticsBiological AgingBiological MarkersBloodBlood Reticuloendothelial SystemBlood VesselsBody CompositionBody TemperatureBody Temperature RegulationBody ThermoregulationBody fatBrainBrain Nervous SystemBrown Adipose TissueBrown FatCardiovascular DiseasesCell BodyCellsCessation of lifeClinical TrialsCognitionCognitiveD-GlucoseDEXADXADataDeathDegenerative Neurologic DisordersDevelopmentDextroseDiseaseDisorderDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryDysfunctionEmotional DepressionEncephalonEndocrineEnergy ExpenditureEnergy MetabolismEpinephrine ReceptorsFDA approvedFastingFatsFatty TissueFatty acid glycerol estersFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGlucoseGlycohemoglobin AGlycosylated hemoglobin AGrip strengthHand StrengthHb A1Hb A1a+bHb A1cHbA1HbA1cHealthHeart failureHeat ProductionHemoglobin A(1)Hibernating GlandHumulin RIncrease lifespanIndirect CalorimetryInsulinInvestigationKetosis-Resistant Diabetes MellitusLaboratoriesLegLipidsLower ExtremityLower LimbMaturity-Onset Diabetes MellitusMeasurementMeasuresMediatingMembrum inferiusMemoryMental DepressionMetabolicMetabolic DiseasesMetabolic DisorderMetabolic dysfunctionMitochondriaMolecularMyocardiumNIDDMNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityOrganOutcomeOveractive BladderPBMCPathologyPathway interactionsPatient Self-ReportPerformancePeripheral Blood Mononuclear CellPeripheral arterial diseasePhasePhenotypePhysical FunctionPhysiologicPhysiologic ThermoregulationPhysiologicalPhysiopathologyPlacebosPredispositionPrimary Senile Degenerative DementiaProcessPsyche structureQOLQuality of lifeRandomizedReceptor ActivationRegular InsulinResearchRespiration CalorimetryRestRiskRisk FactorsRoleSelf AssessmentSelf-ReportSham TreatmentSkeletal MuscleSlow-Onset Diabetes MellitusStable Diabetes MellitusSusceptibilitySystemT2 DMT2DT2DMTestingThermogenesisThermoregulationThesaurismosisTranslatingTransmissionType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVisceralVoluntary MuscleWalkingaccelerated agingaccelerated biological ageaccelerated biological agingadenoreceptoradiposeadiposityadult adiposityadult obesityadult onset diabetesadults with obesityage accelerationage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage specificage specific alterationsage specific changesaging associatedaging associated alterationsaging associated changesaging associated diseaseaging associated disordersaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging processaging relatedaging related alterationsaging related changesaging related diseaseaging related disordersaging specific alterationsaging specific changesalterations with ageanimal databio-markersbiologic markerbiological process of agebiomarkerboost longevitycardiac failurecardiac musclecardiometaboliccardiometabolic riskcardiometabolismcardiovascular disorderchanges with agecircadianclinical efficacyco-morbidco-morbiditycognitive functioncombatcomorbiditycontinuous monitoringcorpulencedecline in functiondecline in functional statusdecreased muscle massdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdepressiondepression symptomdepressivedepressive symptomsdesigndesigningdevelopmentaldisabilitydisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdouble-blind placebo control trialdouble-blind placebo controlled trialdouble-masked controlled trialelongating the lifespanenergy balanceenhance longevityexecutive controlexecutive functionextend life spanextend lifespanextend longevityextracellular vesiclesfastedfastsfoster longevityfrailtyfunctional declinefunctional status declineglucose tolerancehealth related quality of lifehealthy aginghealthy human agingheart musclehemoglobin A1chuman dataimprove lifespanimprove longevityimprovedindexinginnovateinnovationinnovativeketosis resistant diabeteslifespan extensionlow muscle massmaturity onset diabetesmentalmetabolism disordermid lifemid-lifemiddle agemiddle agedmidlifemitochondrialmuscle strengthneurodegenerative illnessnovelolder adultolder adulthoodpathophysiologypathwayperformance based assessmentsperformance based measurementperformance based measuresperipheral artery diseasepharmacologicpleiotropic effectpleiotropismpleiotropypreservationprimary degenerative dementiaprolong lifespanprolong longevitypromote lifespanpromote longevityprotein expressionrandomisationrandomizationrandomly assignedreduced muscle massrepurposingsenile dementia of the Alzheimer typesham therapysocial rolesupport longevitytherapeutic targettransmission processtype 2 DMtype II DMtype two diabetesvascularwearablewearable devicewearable electronicswearable systemwearable technologywearable toolwearableswhite adipose tissueyellow adipose tissue
Description preview
PROJECT SUMMARY
Aging is characterized by the gradual loss of physiological integrity, and this process may be accelerated in the
presence of obesity, increasing susceptibility to disease, frailty, and death. Although the shared molecular
pathways involved have not been fully elucidated, adipose tissue dysfunction is likely a key contributor to…
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