grant
Vestibulopathy, imbalance and gait disturbances in Parkinson disease
Organization VETERANS HEALTH ADMINISTRATIONLocation ANN ARBOR, UNITED STATESPosted 1 Jul 2021Deadline 31 May 2030
VANIHUS FederalResearch GrantFY2026Abnormal gaitActivities of Daily LivingActivities of everyday lifeAcuteAddressAffectAreaBehaviorBilateralBrainBrain Nervous SystemBrain PathologyCausalityChronicClinicalClinical assessmentsCommunitiesCross-Sectional StudiesCross-Sectional SurveyDAT dopamine transporterDataDedicationsDegenerative Neurologic DisordersDenervationDisablingDisease Frequency SurveysDopamineDrugsEligibilityEligibility DeterminationEmergent TechnologiesEmerging TechnologiesEncephalonEquilibriumEtiologyFeasibility StudiesFreezingFrequenciesGaitGait abnormalityGait disorderGait disturbancesGait dysfunctionGait impairmentGoalsHomeHydroxytyramineInterventionKnowledgeLinkLong-Term EffectsMedical RehabilitationMedicationMethodsMotorMovementNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOlder PopulationPETPET ScanPET imagingPETSCANPETTParalysis AgitansParkinsonParkinson DiseaseParticipantPathologicPersonsPharmaceutical PreparationsPhase 2 Clinical TrialsPhase II Clinical TrialsPhysical activityPlayPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrevalencePrimary ParkinsonismProtocol ScreeningQOLQuality of lifeRad.-PETRefractoryRehabilitationRehabilitation therapyResearchResistanceRest TremorRisk FactorsRoleSeveritiesSocietiesTestingVestibularVestibular DiseasesVestibular System ImpairmentVestibular defectVestibular disorderVestibular dysfunctionVestibular problemsVestibular system disorderVestibulopathyVeteransWalking impairmentage associatedage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage correlatedage dependentage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage linkedage relatedage related neurodegenerationage specificage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderbalancebalance functionbody movementcaloric stimulationcausationclinical applicabilityclinical applicationclinical practiceclinical translationclinically translatablecross-sectional research studydaily living functiondaily living functionalitydeconditioningdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisease causationdopamine transporterdrug/agentfall riskfallsfear of fallingfeasibility trialfunctional abilityfunctional capacityhomesimprovedimproved motor functioninnervationmotor function improvementneglectnerve supplyneurodegenerative illnessnovelold ageolder groupsolder individualsolder personphase II protocolportabilitypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyposture instabilityprogramsrehab therapyrehabilitativerehabilitative therapyresistantresponse to therapyresponse to treatmentsedentarysocial roletherapeutic responsetherapy responderstherapy responsetranslational impacttreatment responderstreatment responsetreatment responsivenessvestibular deficitvestibular impairmentvestibular systemvestibular system dysfunction
Description preview
The management of dopamine resistant postural instability and gait difficulty (PIGD) features, such as freezing
of gait (FoG), represents perhaps the most important unmet clinical need in Parkinson's disease (PD).
Research into the role of the vestibular system in the etiology of FoG has largely been neglected. Age-
associated vestibular…
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