🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Vesicle Translocation and the Metabolic Syndrome
Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Apr 2022Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-KinaseAddressAdipocytesAdipose CellAdult-Onset Diabetes MellitusAffectAminopeptidaseAntidiuretic HormoneApoplexyAttenuatedAutoregulationBindingBrain Vascular AccidentC-terminalCardiovascular DiseasesCell BodyCell Communication and SignalingCell SignalingCell membraneCell surfaceCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeComplexCytoplasmic MembraneDataDevelopmentDiabetes MellitusDietDiseaseDisorderDysfunctionDyslipidemiasEndocrine Gland SecretionEnergy ExpenditureEnergy MetabolismEquilibriumEsteroproteasesExerciseFastingFat CellsFatsFatty acid glycerol estersFunctional disorderGLUT 4 proteinGLUT4GLUT4 geneGLUT4 proteinGene ExpressionGene TranscriptionGenetic TranscriptionGlucose Binding ProteinGlucose Transport ProteinGlucose TransporterGoalsGolgiGolgi ApparatusGolgi ComplexHeat ProductionHigh Fat DietHomeostasisHormonesHumulin RHypertensionImpairmentIndividualInsulinInsulin ResistanceIntracellular Communication and SignalingIntracellular MembranesKetosis-Resistant Diabetes MellitusLinkLipocytesLipoprotein ReceptorMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMediatingMembraneMetabolic DiseasesMetabolic DisorderMetabolic syndromeMiceMice MammalsModelingMolecularMolecular InteractionMurineMusMuscleMuscle CellsMuscle TissueMyocytesN-terminalNH2-terminalNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePathogenesisPathway interactionsPeptidasesPeptide HydrolasesPeptidesPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlasma MembranePreventionProcessProtease GeneProteasesProteinasesProteinsProteolytic EnzymesPtdIns 3-KinaseRNA ExpressionRegular InsulinRegulationRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSkeletal MuscleSlow-Onset Diabetes MellitusStable Diabetes MellitusStrokeT2 DMT2DT2DMTestingTherapeutic HormoneThermogenesisThesaurismosisTranscriptionType 2 Diabetes MellitusType 2 diabetesType I Phosphatidylinositol KinaseType II Diabetes MellitusType II diabetesType III Phosphoinositide 3-KinaseVascular Hypertensive DiseaseVascular Hypertensive DisorderVasopressinsVesicleVoluntary MuscleWorkadiposityadult onset diabetesattenuateattenuatesattenuationbalancebalance functionbeta-Hypophaminebiological signal transductionblood glucose regulationbrain attackcardiovascular disordercerebral vascular accidentcerebrovascular accidentcorpulencedevelopmentaldiabetesdietsfastedfastsfat metabolismfatty acid oxidationfatty acylationglucose controlglucose homeostasisglucose metabolismglucose regulationglucose uptakehigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedin vivoinsulin resistantinsulin signalinginsulin toleranceinsulin-responsive glucose transporterketosis resistant diabeteslipid metabolismmaturity onset diabetesmembrane structuremetabolism disordermuscularnew approachesnovel approachesnovel strategiesnovel strategypathophysiologypathwayplasmalemmapreventpreventingsocial rolesortilinstrokedstrokessyntaxinsyntaxin Atraffickingtype 2 DMtype II DMtype two diabetes
Applications closed.
Description preview
Abstract
The regulation of glucose homeostasis is a complex process, which is disrupted in disease states such as type
2 diabetes. Insulin is the primary hormone that regulates glucose homeostasis. Insulin stimulates glucose
uptake in muscle and fat by mobilizing intracellular vesicles containing GLUT4 glucose transporters, which fuse
and insert…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click