grant
VEGF Gene Delivery In The Primate To Prevent Defective Spiral Artery Remodeling And Maternal Vascular Dysfunction
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 8 Sept 2017Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20250-4 weeks old1st trimesterAcetylcholineAquadiolAssayBaboonsBasal PlateBioassayBioavailabilityBiological AssayBiological AvailabilityBirthBlood VesselsBlood capillariesCell BodyCellsCells Placenta-TissueClosure by LigationDefectDeveloping fetusDimenformonDiogynDiogynetsEDRF SynthaseEPH GestosisEarly Placental PhaseEchographyEchotomographyEndothelial CellsEndotheliumEndothelium-Derived Growth Factor SynthaseEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineFLT VEGF ReceptorFLT1 RTKFLT1 Receptor Tyrosine KinaseFetal DevelopmentFetal GrowthFetusFirst Pregnancy TrimesterFirst TrimesterFlt-1FoundationsGene DeliveryGene TargetingGestationGrowth Factor GeneGrowth Factor Proto-OncogeneGuanylyl Cyclase-Activating Factor SynthaseHumanHyperemiaImage AnalysesImage AnalysisImmunofluorescenceImmunofluorescence ImmunologicImpairmentIncidenceInfantInvadedLigationLinkMediatingMedical UltrasoundMessenger RNAMethodsMicrobubblesModalityModelingModern ManMorbidityMorbidity - disease rateMothersNHP modelsNO SynthaseNamesNewborn InfantNewbornsNitric Oxide SynthaseNitric-Oxide SynthetaseNormal PlacentomaOvocyclinOvocylinPapioParturitionPerfusionPerinatalPerinatal MortalitiesPerinatal lethalityPerinatal mortality demographicsPeripartumPhysiologic AvailabilityPlacentaPlacenta Embryonic TissuePlacentomePre-EclampsiaPreeclampsiaPregnancyPregnancy ToxemiasPrimatesPrimates MammalsProgynonProteinsProteinuria-Edema-Hypertension GestosisProto-Oncogene Protein fltPublishingRT-PCRReceptor ProteinReceptor Tyrosine Kinase,Class VResistanceReverse Transcriptase Polymerase Chain ReactionSkeletal MuscleSpiral ArterySpiral Artery of the EndometriumTestingTherapeuticTherapeutic EstradiolTyrosine Protein Kinase FRTTyrosine Protein Kinase Receptor FLTUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUterusVEGFVEGF Receptor flt-1 ProteinVEGFR-1VEGFR1VEGFsVascular DiseasesVascular DisorderVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsVascular remodelingVillousVoluntary Musclearterial remodelingblood vessel disorderbrachial arterycapillarycontrast enhanceddensitydiagnostic ultrasoundearly in pregnancyearly pregnanciesearly pregnancyearly stage of pregnancyfms-Like Tyrosine Kinaseimage evaluationimage interpretationinnovateinnovationinnovativeintra-uterine growthintrauterine growthmRNAmaternal serummortalitynamenamednamingnewborn childnewborn childrennonhuman primate modelsnoveloffspringperinatal deathspre-eclampticpregnancy toxemia/hypertensionpreventpreventingreceptorresistantreverse transcriptase PCRshear stresssite targeted deliverysonogramsonographysound measurementspatial temporal imagingspatial temporal mappingspatiotemporal imagingspatiotemporal mappingtargeted deliverytrophoblastultrasoundultrasound imagingultrasound scanningvascularvascular dysfunctionvasculopathywomb
Description preview
PROJECT SUMMARY/ABSTRACT
During early human pregnancy, placental extravillous trophoblasts invade and remodel the uterine spiral
arteries into distensible low-resistance vessels to promote placental perfusion and thus fetal development. A
defect in uterine spiral artery remodeling (SAR) is the primum movens step that underpins adverse human…
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