grant
Vascular contributions to HIV-associated Neurocognitive Disorders (HAND)
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Aug 2022Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2024(TNF)-αAD dementiaAIDS VirusAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffectAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAmyloid depositionAnti-InflammatoriesAnti-Inflammatory AgentsAnti-Retroviral AgentsAnti-inflammatoryApoplexyBiologicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood VesselsBrain Vascular AccidentBrain Vascular DisordersCD106CD106 AntigensCD54 AntigensCachectinCerebral StrokeCerebrovascular ApoplexyCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeChronicChronic DiseaseChronic IllnessClinicalCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDataDecrease disparityDementiaDiabetes MellitusDiseaseDisorderDisparitiesDisparityDisturbance in cognitionDysfunctionDyslipidemiasElderlyEndotheliumEquipoiseEthnic OriginEthnicityFunctional disorderFutureHIVHIV 1 associated neurocognitive disorderHIV SeronegativitiesHIV SeronegativityHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV disparitiesHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV inequalitiesHIV inequitiesHIV negativeHIV neurocognitive impairmentHIV related disparitiesHIV related inequitiesHIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-associated neurocognitive disorderHIV/AIDS disparitiesHIV/AIDS inequitiesHIV/AIDS related disparitiesHTLV-III SeronegativitiesHTLV-III SeronegativityHealthHomophobiaHomophobicHuman Immunodeficiency VirusesHypertensionICAMICAM-1INCAM-110Impaired cognitionIndividualInducible Cell Adhesion Molecule 110InfectionInflammationInflammatoryInjuryIntercellular Adhesion MoleculesIntercellular adhesion molecule 1Intracranial Vascular DiseasesIntracranial Vascular DisordersKnowledgeLAV-HTLV-IIILassoLife ExpectancyLower disparityLymphadenopathy-Associated VirusMR ImagingMR TomographyMRIMRIsMacrophage-Derived TNFMagnetic Resonance ImagingMeasuresMediatingMediationMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingModificationMonocyte-Derived TNFMorbidityMorbidity - disease rateNMR ImagingNMR TomographyNegotiatingNegotiationNerve DegenerationNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1Neuron DegenerationNuclear Magnetic Resonance ImagingOlder PopulationPathway interactionsPersonsPhysiopathologyPlasmaPlasma SerumPopulationPrevalencePrimary Senile Degenerative DementiaProcessProductionQOLQuality of lifeRecommendationResidualResidual stateReticuloendothelial System, Serum, PlasmaRiskRoleSmokingStrokeStructural RacismSubgroupTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTherapeuticTherapeutic InterventionTranslatingTumor Necrosis FactorTumor Necrosis Factor-alphaVCAMVCAM-1Vascular Cell Adhesion MoleculeVascular Cell Adhesion Molecule-1Vascular DiseasesVascular DisorderVascular Hypertensive DiseaseVascular Hypertensive DisorderVirus-HIVZeugmatographyadvanced ageaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging populationanti-retroviralantiretroviral therapyantiretroviral treatmentbio-markersbiologicbiologic markerbiomarkerblood vessel disorderbrain attackbrain vascular diseasebrain vascular dysfunctioncerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebrovascular accidentcerebrovascular dysfunctionchronic disorderco-morbidco-morbiditycognitive dysfunctioncognitive losscohortcomorbiditycytokinedementia riskdiabetesdisease disparitydisparity reductiongeriatrichigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderinjuriesintercellular cell adhesion moleculeintervention therapyintracranial vascular dysfunctionmitigate disparityneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationolder groupsolder individualsolder personp-taup-τpathophysiologypathwayphospho-tauphospho-τphosphorylated taupopulation agingpost-translational modification of tauposttranslational modification of tauprimary degenerative dementiareduce disparityreduction in disparityrisk factor for dementiarisk for dementiasenile dementia of the Alzheimer typesenior citizensexsocial rolesocial stigmasocio-economicsocio-economicallysocioeconomicallysocioeconomicsstigmastressorstrokedstrokessynergismtau phosphorylationtau posttranslational modificationtau-1therapeutic targetvascularvascular contributionsvascular dysfunctionvascular risk factorvasculopathyτ phosphorylation
Description preview
PROJECT SUMMARY:
As people with HIV (PWH) age, chronic comorbidities such as cerebrovascular disease and poorer cognition become more prevalent. There is a difference in the rates of cerebrovascular disease and dementia among PWH compared with uninfected individuals. Possible contributing factors include disproportionate prevalence of vascular…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click