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Valerobetaine is a microbe-generated metabolite that induces mitochondrial biogenesis and maintains epithelial integrity
Organization EMORY UNIVERSITYLocation ATLANTA, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAffectAlimentary CanalAnimalsAutoregulationBioenergeticsBiogenesisBiologyBiopsyBody SystemBody TissuesCarnitineCausalityCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular Metabolic ProcessCellular ProliferationChronicColitisColonColonoscopesCommunicationComplexDataDevelopmentDigestive TractDiseaseDisorderDysfunctionEnergy ExpenditureEnergy MetabolismEpithelial CellsEpitheliumEtiologyEventExperimental ModelsFamilyForcepFoundationsFunctional disorderGI Stem cellGI TractGI commensalGI microbiomeGI microbiotaGastroenterologyGastrointestinal DiseasesGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGene ExpressionGenerationsGerm-FreeGnotobioticGnotobioticsGoalsGrantGut EpitheliumHealthHepatic CellsHepatic Parenchymal CellHepatocyteHomeostasisImmune responseIn VitroIndolesInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInjuryIntermediary MetabolismIntestinalIntestinal LeakageIntestinesKnowledgeLeaky GutLiver CellsMaintenanceMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetabolic ProcessesMetabolismMethodologyMethodsMiceMice MammalsMicrobeMitochondriaModelingModificationMolecularMorbidityMorbidity - disease rateMurineMusOrgan SystemOrganoidsOrigin of LifePersonsPhenotypePhysiological HomeostasisPhysiologyPhysiopathologyPlayProliferatingQOLQuality of lifeResearchRisk FactorsRoleScienceScientistShort-Chain Fatty AcidsSignal PathwayTestingTherapeuticTissuesTrainingVolatile Fatty AcidsWorkWound modelsalimentary tractbeneficial florabeneficial microbesbeneficial microflorabeneficial microorganismbowelbowel inflammationcausationcell metabolismcellular metabaolismcolitis mouse modelcolitis murine modelcommensal bacteriacommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensal bacterial speciesdevelopmentaldigestive canaldigestive tract microbiomedisease causationenteric commensalenteric microbial communityenteric microbiomeenteric microbiotafatty acid oxidationfunctional plasticitygastrointestinal commensalgastrointestinal disordergastrointestinal epitheliumgastrointestinal microbial floragastrointestinal microbiomegastrointestinal stem cellgut commensalgut communitygut floragut healthgut homeostasisgut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut progenitorgut stem cellgut-associated microbiomehost microbiomehost responseimmune system responseimmunoresponsein vivoinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinjuriesinterestintestinal autoinflammationintestinal biomeintestinal commensalintestinal cryptintestinal epitheliumintestinal floraintestinal inflammationintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal progenitorintestinal stem cellsintestinal tract microflorametabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial antigenmicrobial consortiamicrobial floramicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremicrobiotamicrofloramicroorganism antigenmitochondrialmitochondrial metabolismmouse colitismouse modelmultispecies consortiamurine colitismurine modelnovelpathophysiologypreservationprogenitor cell nicheprogenitor nicheresponsesmall moleculesocial rolestem and progenitor cell nichestem cell nichetherapeutic targetthree dimensionalwound healing models
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SUMMARY
Inflammatory Bowel Disease (IBD) is a debilitating condition that contributes to high morbidity and poor quality
of life. A risk factor for the development of IBD is a ‘leaky gut’ phenotype where elevated amounts of microbially-
derived antigenic material traverse the gut epithelium into sub-epithelial compartments provoking a dysregulated…
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