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Uteroplacental Vasculature and Fetal Growth after Plastic Particle Exposure
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 1 Sept 2023Deadline 19 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAdult femalesAdult womenAdverse effectsAffectAirAir PollutionAnimalsAreaArteriesBiologicalBiologyBloodBlood Reticuloendothelial SystemBlood VesselsBlood flowBody TissuesCardiometabolic DiseaseCardiometabolic DisorderCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCells Placenta-TissueCellular FunctionCellular PhysiologyCellular ProcessCommon Rat StrainsDataDeveloping fetusDevelopmentDiffusionDiseaseDisorderDistalENOSEndogenous Nitrate VasodilatorEndothelial CellsEndothelial Nitric Oxide SynthaseEndotheliumEndothelium-Derived Nitric OxideExposure toFellowshipFemaleFemales in adulthoodFetal Body WeightFetal DevelopmentFetal GrowthFetal Growth RestrictionFetal Growth RetardationFetal TissuesFetal WeightFetusGeneral PopulationGeneral PublicGeneralized GrowthGestationGrantGrowthHealthHeart VascularHourHumanIUGRImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentInhalationInhalingInternal EarInternationalInterventionIntracellular Communication and SignalingIntrauterine Growth RetardationInvadedKnowledgeLaboratoriesLabyrinthLeiomyocyteLungLung ParenchymaLung Respiratory SystemLung TissueMaternal-Fetal ExchangeMeasuresMechanicsMediatorModelingModern ManMolecular TargetMononitrogen MonoxideMorphogenesisMothersMyographyNOS3NOS3 geneNitric OxideNitric Oxide Synthase 3Nitrogen MonoxideNitrogen ProtoxideNormal PlacentomaNutrientNylonsO elementO2 elementOccupational ExposureOrganOxygenParticulate MatterPathway interactionsPerinatal MortalitiesPerinatal lethalityPerinatal mortality demographicsPhysiologyPlacentaPlacenta Embryonic TissuePlacental DevelopmentPlacentationPlacentomePlasticsPolyamidesPredispositionPregnancyPregnant WomenPrincipal InvestigatorProcessRatRats MammalsRattusResearchRisk AssessmentSignal TransductionSignal Transduction SystemsSignalingSiteSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSpiral ArterySpiral Artery of the EndometriumStructureStructure of parenchyma of lungSubcellular ProcessSurfaceSusceptibilityTechniquesTestingTherapeutic InterventionTissue GrowthTissuesToxicologyTrainingTranslatingTransplacental ExposureType III nitric oxide synthaseUterusVascular Smooth MuscleVasodilatationVasodilationVasorelaxationVulnerable PopulationsWeightWomen in adulthoodadulthoodair filterangiogenesisarteriolebiologicbiological signal transductionbiomass fuelcardiometabolic riskcirculatory systemconstrictiondevelopmentaldiffuseddiffusesdiffusingdiffusionsendothelial cell derived relaxing factorendothelial dysfunctionexpectant motherexpectant womenexpecting motherexpecting womenfetus tissuehemodynamicsimpaired fetal growthindividuals who are pregnantindoor PMindoor air particulate matterindoor fine particlesindoor particulate matterinfant morbidityinfant morbidity/mortalityinner earintervention therapyintra-uterine growthintra-uterine growth restrictionintra-uterine growth retardationintra-vital microscopyintrauterine growthintrauterine growth restrictionintravital microscopymaternal-fetal interfacemechanicmechanicalmigrationmorphogenetic processnano particlenano-sized particlenanoparticlenanosized particleontogenyparticleparticle exposurepathwaypeople who are pregnantperinatal deathspharmacologicpregnantpregnant femalespregnant motherspregnant peoplepregnant populationsprenatal growth disorderpressureprotein expressionpulmonaryradial arteryreproductivetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targetthose who are pregnanttoolvascularvulnerable groupvulnerable individualvulnerable peopleweightswombwomen who are pregnantworkplace exposure♀
Applications closed.
Description preview
PROJECT SUMMARY/ABSTRACT
In humans, fetal growth restriction (FGR) and impaired placental development are associated with infant
morbidity and mortality and susceptibility to adulthood diseases. In pregnant animals, inhalation of particles alters
the functionality of the uteroplacental vasculature, leading to impaired placental and fetal growth.…
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