grant
Using natural products to decipher essential host-parasite interactions in visceral leishmaniasis.
Organization FORT LEWIS COLLEGELocation DURANGO, UNITED STATESPosted 10 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Antiparasitic AgentsAntiparasitic DrugsAntiparasiticsAttenuatedAutophagocytosisAutophagosomeBasal Transcription FactorBasal transcription factor genesBasic ResearchBasic ScienceBioinformaticsBiteCell BodyCellsCessation of lifeConfocal MicroscopyContracting OpportunitiesContractsCoupledDataDeathDefense MechanismsDisease ProgressionDrug Metabolic DetoxicationDrug Metabolic DetoxificationDrug resistanceEnsureEnzyme GeneEnzymesErythroidFluorescence Light MicroscopyFluorescence MicroscopyGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGlutathioneGoalsHealthHepatosplenomegalyHumanImmuneImmune responseImmunesImmunomodulationInfectionInnate Immune ResponseInterventionInvestigatorsKala-AzarKnock-outKnockoutL donovaniL. donovaniLeishmaniaLeishmania (Leishmania) donovaniLeishmania (Leishmania) infantumLeishmania donovaniLeishmania donovani chagasiLeishmania donovani infantumLeishmania infantumLeishmaniasisLife CycleLife Cycle StagesMacrophageMalariaMetabolic Drug DetoxicationsMetabolism of Toxic AgentsModern ManMφNF-E2 proteinNF-E2 transcription factorNFE2 proteinNatural ProductsNuclearOutcomeOxidative StressPaludismParasitesParasitic DiseasesParasitic infectionParasiticidesPathway interactionsPatientsPersonsPhlebotominaePhytochemicalPlasmodium InfectionsPrevalencePropertyProtein AnalysisProteinsPublishingResearchResearch PersonnelResearchersRoleStudentsSulfaforaphaneSulforaphaneTestingTranscription Factor Proto-OncogeneTranscription factor genesTransmissionUS StateVacuoleVisceral LeishmaniasisWorkaltered natural productattenuateattenuatesautophagydetoxificationdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedrug developmentdrug resistantextracellulargamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycinehost responseimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedinfected with parasitesinhibition of autophagylife coursemethylsulfoxybutylisothiocyanatemodified natural productnaturally occurring productneglectneglected tropical diseasesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynuclear factor-erythroid 2parasite infectionpathogenpathwayplant compoundplant derived compoundpsychological defense mechanismresistance strainresistance to Drugresistant strainresistant to Drugresponsesandflysocial rolestudent researchstudent-led researchsulforafansulforophanetailored natural producttranscription factortranscriptomicstranslational impacttransmission processundergraduate researchvaccine developmentvector-bornevectorborne
Description preview
1 PROJECT SUMMARY:
2 Visceral leishmaniasis is a vector-borne neglected tropical disease (NTD) caused by Leishmania
3 donovani and Leishmania infantum. During infection, Leishmania parasites alter host responses in
4 innate immune cells, such as macrophages (MΦ’s), to ensure parasite survival and replication in the
5 parasitophorous vacuole…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click