grant
Using natural killer cells to prevent breast cancer metastases
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAdvisory CommitteesAntibodiesAssayAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBehaviorBioassayBioinformaticsBiological AssayBiometricsBiometryBiostatisticsBody TissuesBreast CancerBreast Cancer CellBreast Cancer PatientBreast Cancer PreventionBreast Cancer therapyBreast MetastasisBreast Tumor PatientCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell ReprogrammingCell SignalingCell Surface ReceptorsCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular biologyClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-cultureCocultivationCocultureCoculture TechniquesCombined Modality TherapyCytotoxic cellDNA MethyltransferaseDNA Modification MethylasesDNA Modification MethyltransferasesDNA methyltransferase inhibitionDNA-MethyltransferasesDataDiseaseDisorderDisseminated Malignant NeoplasmDnmtECMEnvironmentEventExtracellular MatrixFOSL1FOSL1 geneFRA1Fos-Like Antigen 1 GeneFrequenciesFundingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionHumanImmuneImmune SurveillanceImmune mediated therapyImmunesImmunologic SurveillanceImmunologically Directed TherapyImmunosurveillanceImmunotherapyIn SituIndividualInduction of ApoptosisIntracellular Communication and SignalingK CellsK lymphocyteKiller CellsKnowledgeLectinLigandsLinkLytotoxicityMalignant Breast NeoplasmMalignant CellMentorsMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorMetastatic breast cancerModelingModern ManModification MethylasesMolecularMolecular FingerprintingMolecular ProfilingMultimodal TherapyMultimodal TreatmentNK CellsNatural Killer CellsNeoplasm MetastasisOrganOrganoidsPatientsPhenotypePhysiciansPlayPostdocPostdoctoral FellowRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinResearch AssociateRoleSamplingScientistSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSiteSite-Specific DNA-methyltransferaseTask ForcesTechniquesTestingTherapeuticTimeTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTumor Celladvisory teambiological signal transductionbiomarker identificationbreast cancer metastasisbreast tumor cellcancer cellcancer metastasiscancer microenvironmentcell biologycellular reprogrammingcombination therapycombined modality treatmentcombined treatmentcytotoxiccytotoxicitydifferential expressiondifferentially expresseddrivingeffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsidentification of biomarkersidentification of new biomarkersimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedin vivoin vivo Modelindividuals with breast cancerinhibitorinsightkiller factorkiller substancekiller toxinlive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignant breast tumormammary cancer preventionmammary tumor preventionmarker identificationmetastatic breast tumormetastatic mammary cancermetastatic mammary tumormolecular profilemolecular signaturemortalitymouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplastic cellnovelpatients with breast cancerperson with breast cancerpharmacologicpost-docpost-doctoralpost-doctoral traineepre-clinicalpreclinicalprevent breast cancerprogramspromoterpromotorreceptorresearch associatesrestraintscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuccesstherapeutic targetthree dimensionaltooltranscription factortranscriptional differencestranscriptome sequencingtranscriptomic sequencingtranscriptomicstumortumor cell metastasistumor growthtumor microenvironment
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Project Summary/Abstract
Most of breast cancer related mortality is related to metastatic disease. While NK cells play an essential role in
the control of metastatic breast cancer we do not fully understand key mechanistic and temporal events of NK
cell immunosurveillance. To address this need, I created novel 3D co-culture assays of NK cells and…
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