grant

Using Experimental Evolution to Evaluate Environmental Effects on Microbial Mutation and Adaptation

Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 8 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Active Follow-upAffectAnaerobic BacteriaCommunicable DiseasesCompetenceComplexDNA mutationE coliE. coliEnvironmentEscherichia coliEvolutionFaceFaminesFutureGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGrowthHuman MicrobiomeInfectious DiseasesInfectious DisorderIntermediary MetabolismInvestigationKnowledgeLaboratoriesLactobacillusLifeLife StyleLifestyleMetabolicMetabolic ProcessesMetabolismMicrobeMicrobial PhysiologyMicrobiologyMolecularMutationMutation SpectraNatureNutrientNutritionalO elementO2 elementOutcomeOxygenPatternPhenotypePopulationProcessResearchResearch ResourcesResourcesSeveritiesShapesStarvationStressSystemTissue GrowthTreesactive followupanaerobeanti-microbialantimicrobialbehavior phenotypebehavioral phenotypingcommensal floracommensal microbescommensal microbiotacommensal microfloradisease preventiondisorder preventionexperimentexperimental researchexperimental studyexperimentsfacesfacialfeedingfitnessfollow upfollow-upfollowed upfollowupgenome mutationhuman-associated microbiomemicrobe pathogenmicrobialmicrobial pathogenmicroorganismmultiomicsmultiple omicsneglectnew approachesnovelnovel approachesnovel strategiesnovel strategynutritiousontogenypanomicspathogenic microberesponsetranscriptomics
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PROJECT SUMMARY
In nature and human microbiomes, microbes regularly face challenges due to fluctuations in the availability of

resources and nutrients - a lifestyle termed feast/famine. Previous studies investigating microbial adaptation to

feast/famine have focused on the specific adaptations that allow microbes to survive extreme starvation,…

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Using Experimental Evolution to Evaluate Environmental Effects on Microbial Mutation and Adaptation — VANDERBILT UNIVERS | Dev Procure