grant
Using bile salt metabolism to modulate CDI prophylaxis
Organization UNIVERSITY OF NEVADA LAS VEGASLocation LAS VEGAS, UNITED STATESPosted 1 Dec 2014Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AcidsAddressAmidesAnabolismAnilineAnimal TestingAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAntigenic DeterminantsAutoregulationBacteriaBenchmarkingBenzoxazolesBest Practice AnalysisBindingBinding DeterminantsBinding ProteinsBinding SitesBiotransformationC diffC difficileC. diffC. difficileCell BodyCellsCessation of lifeCholatesClostridioides difficileClostridium difficileColitisCombining SiteComplexCricetinaeDataDeathDevelopmentDiarrheaDiseaseDisorderDrug KineticsEntero-Hepatic CirculationEnterohepatic CirculationEnvironmentEpitheliumEpitopesFundingGI microbiomeGI microbiotaGastrointestinal microbiotaGene TranscriptionGenetic TranscriptionGenetics-MutagenesisGerminationGoalsHamstersHamsters MammalsHarvestHealth Care CostsHealth Care SystemsHealth CostsHomeostasisHospital AdmissionHospitalizationHospitalsHumanHydrolysisHydroxylationIn VitroIn vivo analysisIndividualInfectionIntermediary MetabolismIntestinalIntestinesKnock-outKnockoutLD-50LD50LeadLethal Dose 50LibrariesLigand Binding ProteinLigand Binding Protein GeneLinkLiverLytotoxicityMediatingMedicinal ChemistryMetabolicMetabolic BiotransformationMetabolic ProcessesMetabolismMethodsMiceMice MammalsMicrosomesMiscellaneous AntibioticModern ManMolecularMolecular InteractionMurineMusMutagenesisMutagenesis Molecular BiologyNI220NI220/250NOGONOGOANOGOBNOGOCNeurite Growth Inhibitor 220Neurite Outgrowth InhibitorPatientsPb elementPermeabilityPharmaceutic ChemistryPharmaceutical ChemistryPharmacodynamicsPharmacokineticsPhysiological HomeostasisPreclinical dataPredispositionProcessPropertyProphylactic treatmentProphylaxisProtein BindingProteinsProteomicsQSARQuantitative Structure-Activity RelationshipQuantitiative Structure Activity RelationshipQuinazolinesRNA ExpressionRTN4RTN4 geneReactive SiteRegulationRelapseReproduction sporesReticulon 4RodentRodentiaRodents MammalsRoleSchemeSideSporesSteraneSumSusceptibilitySymptomsTaurine CholateTaurocholateTestingToxic effectToxicitiesToxicity TestingToxicity TestsToxinTranscriptionTranslationsUncertaintyVancomycinanaloganti-bacterialantibiotic-associated diarrheabenchmarkbenzenaminebenzimidazolebenzothiazolebile saltsbiosynthesisbound proteinbowelchenodeoxycholatecholeatecost estimatecost estimationcytotoxicitydehydroxylationdeoxycholatedevelopmentaldigestive tract microbiomedosagedoubtenteric microbial communityenteric microbiomeenteric microbiotaexperiencegastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomeheavy metal Pbheavy metal leadhepatic body systemhepatic organ systemin vitro testingin vivoin vivo evaluationin vivo testinginfection riskintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microflorametermicrobialmicrobial consortiamicrobial floramicrobiotamicrofloramultispecies consortiapreclinical findingspreclinical informationpreventpreventingprogramsprophylacticpublic health relevancesocial rolesymptomatologytranslationuptake
Description preview
Abstract
Clostridium difficile infection (CDI) is the main identifiable cause of antibiotic assoicated diarreah. in the
US alone, there are close to 500,000 cases annually causing approximately 25,000 deaths and costs the
health care system an estimated $6.3 billion.
C. difficile spores do not cause disease but can revert to toxin-producing…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click