grant
Upper Gastrointestinal Cancer Studies
Organization DIVISION OF CANCER EPIDEMIOLOGY AND GENETICSLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAblationAbscissionAcetaldehydeActive Follow-upAdenocarcinoma of the Cardia of the StomachAdultAdult HumanAgeAnimalsAntibodiesApoplexyAreaAromatic Polycyclic HydrocarbonsBeveragesBiopsyBlack TeaBlood SerumBody TissuesBrain Vascular AccidentBrazilC pyloriC. pyloriCampylobacter pyloriCancer CauseCancer EtiologyCancer InductionCancer TreatmentCancersCardiaCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCarotenes and CarotenoidsCarotenoidsCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCausalityCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeCharacteristicsChinaClinicClinicalCohort StudiesConcurrent StudiesConsumptionCountyDNADeathDeath RateDental HygieneDeoxyribonucleic AcidDevelopmentDiagnosisDietary InterventionDiseaseDisorderDoseDrynessDysplasiaEarly DiagnosisEarly treatmentEnrollmentEnvironmental FactorEnvironmental Risk FactorEsophageal CancerEsophageal Epidermoid CarcinomaEsophageal SCCEsophageal Squamous Cell CarcinomaEsophageal TissueEsophagusEsophagus CancerEthanalEthnic OriginEthnicityEtiologyEvaluationEvaluation StudiesExcisionExtirpationFeasibility StudiesFreezingFumonisinsGI cancersGI malignanciesGI tract cancersGastric Body CancerGastric CancerGastric Cardia AdenocarcinomaGastric Cardia CancerGastric Fundus CancerGastric Pylorus CancerGastrointestinal CancerGastrointestinal Tract CancerGeneral PopulationGeneral PublicGenetic PolymorphismGenetic RiskGenetic predisposing factorGeographyGlucuronidesGoiterH pyloriH pyloryH. pyloriH. pyloryHPVHPV 16HPV 18HPV oncogeneHPV-16HPV-18HPV16HPV18Heart VascularHelicobacter pyloriHigh grade dysplasiaHuman Papilloma VirusHuman PapillomavirusHuman papilloma viral oncogeneHuman papilloma virus type 16Human papilloma virus type 18Human papillomavirus 16Human papillomavirus 18Human papillomavirus type 16Human papillomavirus type 18In complete remissionIndividualInfectious Human Wart VirusIntervention TrialInterventional trialIodineIranKenyaLaboratoriesLesionMainland ChinaMalignant Esophageal NeoplasmMalignant Esophageal TumorMalignant Gastric NeoplasmMalignant Gastric TumorMalignant Gastrointestinal NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the EsophagusMalignant neoplasm of esophagusMalignant neoplasm of gastrointestinal tractMeasuresMethodsMineralsNeighborhoodsNutrition InterventionsNutritional InterventionsOral HygieneParticipantPartner in relationshipPatient Self-ReportPatientsPersonsPopulationPreventative strategyPreventionPrevention strategyPreventive strategyProbabilityPrognosisProvinceRF ablationRadio Frequency AblationRadiofrequency AblationRadiofrequency Interstitial AblationRandomizedRemovalResearch SpecimenResidualResidual stateResolutionRiskRisk FactorsRoleRuminantiaRuminantsSCC of the EsophagusSamplingSe elementSeleniumSelf-ReportSerologySerumSolateneSpecimenSquamous Cell Carcinoma of the EsophagusStaining methodStainsStomachStomach CancerStrokeSupplementationSurgical RemovalSymptomsTeaTechniquesTemperatureTestingTissuesTobacco ConsumptionTobacco useTooth LossUpper GIUpper GI TractUpper Gastrointestinal TractUpper digestive tract structureVital StatusVitamin EVitaminsZincZn elementactive followupadulthoodagesanti-cancer therapybeta,beta-Carotenebrain attackcancer riskcancer therapycancer-directed therapycarcinogenesiscarotenoid biosynthesiscase-controlled studiescausationcerebral vascular accidentcerebrovascular accidentcirculatory systemcohortcomplete responsedesigndesigningdevelopmentaldiet interventiondisease causationdrinkingdyscrasiaearly detectionearly therapyendomicroscopyenrollenvironmental riskfield based datafield learningfield studyfield testfollow upfollow-upfollowed upfollowupgastricgastric cardiagastric malignancygastrointestinal malignanciesgenetic risk factorhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhuman papilloma virus 16human papilloma virus 18human papilloma virus oncogenehuman papillomaviral oncogenehuman papillomavirus oncogeneinherited factorinsightlow SESlow socio-economic positionlow socio-economic statuslow socioeconomic positionlow socioeconomic statusmalignancymalignant stomach neoplasmmalignant stomach tumormalleable riskmatemicroendoscopymodifiable riskmolecular biomarkermolecular markermortalitymortality ratemortality rationeoplasm/canceroesophageal canceropium usepolyaromatic hydrocarbonspolymorphismpolynuclear aromatic hydrocarbonrandomisationrandomizationrandomly assignedresectionresolutionsresponsescreeningscreeningssocial rolestomach cardiastomach fundus cancerstomach pylorus cancerstrokedstrokestobacco product usetumortype 16 Human papilloma virustype 16 Human papillomavirusupper GI cancerupper gastrointestinal cancerurinarywart virusα-Tocopherolβ-Carotene
Description preview
BACKGROUND: Gastric cancer and esophageal cancer are the second and sixth most common causes of cancer death worldwide. Both of these upper gastrointestinal tract (UGI) cancers have a very poor prognosis, largely because symptoms usually do not occur until late in the disease. Significant reduction in UGI cancer mortality will probably require…
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