grant
Unravelling immunoregulatory circuits of tissue inflammation
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAPECEDAccelerationActive Follow-upAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAmericanAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAutocrine SystemsAutoimmuneAutoimmune DiseasesAutoimmune Polyendocrinopathy with Candidiasis and Ectodermal DystrophyAutoimmune Polyendocrinopathy-Candidiasis-Ectodermal-DystrophyAutoimmune StatusAutoimmune polyendocrine syndrome type 1Autoimmune polyglandular syndrome type 1AutoimmunityAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBACH2BACH2 geneBTB and CNC Homology 2Basal Transcription FactorBasal transcription factor genesBasic Leucine Zipper Transcription Factor 2BehaviorBenchmarkingBest Practice AnalysisBiologicalBiological MarkersBiologyBladder CancerBlood PlasmaBody TissuesBrain InflammationC5AR2C5AR2 geneC5L2CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCDK2CDK2 geneCOVID infected patientCOVID patientCOVID positive patientCOVID-19COVID-19 infected patientCOVID-19 patientCOVID-19 positive patientCOVID-19 virusCOVID19 patientCOVID19 positive patientCOVID19 virusCV-19Cancer InductionCancersCell BodyCell Communication and SignalingCell Division Kinase 2Cell LineageCell LocomotionCell MigrationCell MovementCell SignalingCellsCellular MigrationCellular MotilityCellular biologyCicatrixClinicalCoV-2CoV2CollaborationsCommunicable DiseasesCommunicationComplementComplement 5Complement C5Complement Component 5Complement ProteinsComplement component C5ComplexComputing MethodologiesCoronavirus Infectious Disease 2019Cyclin-Dependent Kinase 2DataData SetDevelopmentDisciplineDiseaseDisorderDrugsEGR2EGR2 geneEncephalitisEnhancersEnvironmentEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEventFKHRFOXO1FOXO1AFOXO1A geneFailureFolateFolic AcidForkhead Box O1AForkhead in RhabdomyosarcomaFunctional RNAFunctional impairmentG Protein-Coupled Receptor 77GPR77Gene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionHumanIL1R2IL1R2 geneIL1RBImmuneImmune systemImmunesImmunityImmunologyImmunomodulationImmunosuppressantsImmunosuppressionImmunosuppression EffectImmunosuppressive AgentsImmunosuppressive EffectImmunosuppressive drugImmunosuppressive treatmentInfectionInfectious DiseasesInfectious DisorderInflammationInflammatoryInjuryInterferon Type IIntracellular Communication and SignalingInvestigatorsJUN Family GeneJUN Proto-oncogene FamilyJUN geneJobsJournalsKROX20KidneyKidney DiseasesKidney Urinary SystemKnowledgeLifeLinkLymphatic cellLymphocyteLymphocyticMagazineMalignant Bladder NeoplasmMalignant NeoplasmsMalignant TumorMalignant Tumor of the BladderMalignant neoplasm of urinary bladderMammaliaMammalsMediatingMediatorMedicalMedicationMedicineMiceMice MammalsModelingModern ManMolecularMorbidityMorbidity - disease rateMurineMusMyeloid Cell ActivationNCATSNational Center for Advancing Translational SciencesNatureNeoplastic Cell TransformationNephropathyNew EnglandNon-Polyadenylated RNANoncoding RNANontranslated RNANortheastern United StatesOccupationsOrganPaperPathogenicityPathway interactionsPatientsPharmaceutical PreparationsPhysiologyPlasmaPlasma SerumPolyglandular Autoimmune Syndrome Type IPrintingProcessProfessional PositionsProstacyclinsProstaglandins IPsoriasisPteroylglutamic AcidPublicationsPublishingRNARNA ExpressionRNA Gene ProductsRegulationRegulatory T-LymphocyteRenal DiseaseRenal functionReportingRepressionResearchResearch PersonnelResearch ResourcesResearchersResolutionResourcesRespiratory EpitheliumReticuloendothelial System, Serum, PlasmaRibonucleic AcidRiskRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 infected patientSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2STAT3STAT3 geneScarsScienceScientific PublicationSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2ShapesSignal InductionSignal TransductionSignal Transduction SystemsSignalingSkinStructure of respiratory epitheliumSyndromeSystemT cell differentiationT-Cell ActivationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTherapeuticTherapeutic FungicidesTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTregUntranslated RNAUrinary Bladder CancerUrinary Bladder Malignant TumorVIT DVitamin DVitamin D DeficiencyVitamin MWorkWuhan coronavirusactivate T cellsactive followupacute kidney injuryadaptive immunityafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionairway epitheliumantagonismantagonistanti-fungalanti-fungal agentsanti-fungal drugautocrineautoimmune conditionautoimmune disorderautoimmune polyendocrine syndrome type Iautoimmune polyendocrinopathy syndrome type 1autoimmunity diseasebenchmarkbio-markersbiologicbiologic markerbiological signal transductionbiomarkerc junc-jun Genecarcinogenesiscell biologycell motilitycomplementationcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcoronavirus disease 2019coronavirus disease 2019 infected patientcoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19coronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientdevelopmentaldrivingdrug/agentepidemiologicepidemiologicalepigeneticallyfollow upfollow-upfollowed upfollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectionfollowupgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehCoV19healingimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive agentimmune suppressive functionimmune suppressorimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunosuppressive substanceimmunosuppressorimprovedinhibitorinjuriesinjury and repairinsightinterestkidney disorderkidney functionlife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2lymph cellmalignancymodel of animalmortalitynCoV2neoplasm/cancerneoplastic transformationnoncodingnovelparacrinepathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2post SARS-CoV-2 infectionpreventpreventingprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionprognosticprogramspsoriasiformpsoriaticrecruitregulatory T-cellsrenalrenal disorderresolutionsrespiratory tract epitheliumresponseserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2social rolethymus derived lymphocytetooltranscription factortranscriptomevitamin Bc
Description preview
In the past years we had shown that cell-autonomous Complement is produced both from immune and non-immune cells and delineated the major pathways of their induction, notably LFA-1-induced signals in T cells and type I interferons in respiratory epithelial cells. These findings were important because they indicated that inflamed tissues, which are…
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