grant
Unraveling the Role of Tandem Repeats and Structural Variants in Addiction-Related Behaviors Using Heterogeneous Stock Rats
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AddressAffectAwarenessBehaviorBehavioralBehavioral GeneticsBioinformaticsBiologic SciencesBiologicalBiological SciencesBioscienceBody WeightCatalogsCell Communication and SignalingCell SignalingCommon Rat StrainsCommunitiesComplexComplex Genetic TraitComputing MethodologiesDataDrug abuseDrugsFundingGI microbiomeGWA studyGWASGene ExpressionGene variantGenesGeneticGenetic Determinants of BehaviorGenetic DiversityGenetic VariationGenetic studyGenomeGenotypeGoalsHaplotypesHumanHuman GeneticsHuman GenomeInbred StrainInbreedingIntracellular Communication and SignalingLife SciencesLinkMapsMedicationMental disordersMental health disordersMethodsModern ManNational Institutes of HealthNaturePharmaceutical PreparationsPhenotypePopulationPreventative strategyPrevention strategyPreventive strategyPsychiatric DiseasePsychiatric DisorderPublic HealthQTLQuantitative Trait LociRatRats MammalsRattusResearchResearch ResourcesResourcesRodentRodentiaRodents MammalsRoleSample SizeSamplingSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSourceSurvey InstrumentSurveysTandem Repeat SequencesTandem RepeatsTechniquesTechnologyTrainingUnited States National Institutes of HealthVariantVariationWorkabuse of drugsabuses drugsaddictionaddictive disorderallelic variantbehavior geneticsbiologicbiological signal transductioncatalogcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddata imputationdigestive tract microbiomedrug abuse related behaviordrug/agententeric microbiomeentire genomefull genomegastrointestinal microbiomegene locusgenetic architecturegenetic locusgenetic variantgenome sequencinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusgenomic variantgut microbiomegut-associated microbiomehuman whole genomeimputation methodinnovateinnovationinnovativeinsightintestinal biomeintestinal microbiomelong read seqlong-read sequencinglong-read transcript sequencingmental illnessmethod developmentmodel organismnano porenanoporeneglectnoveloverdose deathoverdose fatalitiespreventpreventingpsychiatric illnesspsychological disorderrat genomesingle nucleotide variantskillssocial rolestructural mutationstructural variantstructural variationtherapeutic targettraittreatment strategywhole genomewhole genome association analysiswhole genome association study
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Project Abstract
Drug abuse is a significant public health crisis, with over 106,000 drug-involved overdose deaths in the U.S. in
2021. Human genome-wide association studies (GWAS) have started to identify underlying causal genetic loci
in addiction, but most of them sacrifice phenotypic granularity in order to obtain larger sample sizes. GWAS in…
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