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Unraveling satellite glial cells dysfunctions in spiral ganglia of a mouse model of Fragile X syndrome
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025ASDAction PotentialsAdolescentAdolescent YouthAffectAfferent NeuronsAnxietyAuditoryAuditory systemAutismAutistic DisorderAxonBehavioralBrainBrain Nervous SystemCandidate Disease GeneCandidate GeneCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCochleaCochlear OrganCognitive deficitsCommunicationCorti CellCorti ganglionDataData AnalysesData AnalysisDefectDevelopmentDissociationDorsal Root GangliaDysfunctionEarEarly Infantile AutismElectron MicroscopyEncephalonEnvironmentEscalante syndromeExpression SignatureFMR-1 ProteinFMR1 ProteinFMR1 geneFMRPFMRP proteinFRAXAFoundationsFragile XFragile X Mental Retardation 1 GeneFragile X Mental Retardation ProteinFragile X SyndromeFunctional disorderFutureGene ExpressionGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGliaGlial CellsGoalsHair CellsHearingHypersensitivityImmuneImmunesImmunofluorescenceImmunofluorescence ImmunologicImpairmentIn Situ HybridizationInfantile AutismKanner's SyndromeKnowledgeKolliker's reticulumMartin-Bell SyndromeMartin-Bell-Renpenning syndromeMediatingMembraneMiceMice MammalsMolecular FingerprintingMolecular ProfilingMurineMusMyelinNerve CellsNerve UnitNeural CellNeural DevelopmentNeurilemma CellNeurilemmal CellNeurocyteNeurodevelopmental DisorderNeurogliaNeuroglial CellsNeurological Development DisorderNeuronsNociceptionNon-neuronal cellNonneuronal cellPeripheralPeripheral Nervous SystemPhysiopathologyPropertyProprioceptionRNA ExpressionRenpenning syndrome 2RoleSchwann CellsSensorySensory GangliaSensory NeuronsSocial InteractionSpecificitySpeedSpinal GangliaSurfaceTranscriptionTransmissionWhole-Cell RecordingsX-linked mental deficiency-megalotestes syndromeX-linked mental retardation with fragile X syndromeX-linked mental retardation-fragile site 1 syndromeadult youthauditory stimulusautism spectral disorderautism spectrum disorderautism-fragile X (AFRAX) syndromeautistic spectrum disordercandidate validationcell envelopecell typecognitive defectsdata interpretationdevelopmentaldorsal root ganglionear hair cellexperimentexperimental researchexperimental studyexperimentsfra(X) syndromefra(X)(28) syndromefra(X)(q27) syndromefra(X)(q27-28) syndromefragile X FMR1 proteinfragile X mental retardation 1fragile X mental retardation-1 proteinfragile X-mental retardation syndromefragile Xq syndromefragile site mental retardation 1gene expression patterngene expression signatureglial cell developmentglial developmentglobal gene expressionglobal transcription profilein situ Hybridization Geneticsin situ Hybridization Staining Methodinnovateinnovationinnovativejuvenilejuvenile humanmacro-orchidism-marker X (MOMX) syndromemacro-orchidism-marker X syndromemar(X) syndromemarker X syndromemembrane structuremental retardation-macroorchidism syndromemolecular profilemolecular signaturemouse modelmurine modelmyelinationnerve cementneural cell bodyneurodevelopmentneurodevelopmental diseaseneuron developmentneuronalneuronal cell bodyneuronal developmentneuronal excitabilitynociceptivepathophysiologypostnatalresponsescRNA sequencingscRNA-seqsensory inputsensory mechanismsignal processingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesomasoundspiral gangliontimelinetranscriptional profiletranscriptional signaturetranscriptometransmission processyoung adultyoung adult ageyoung adulthood
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ABSTRACT
Sensory neurons convey information about external and internal environment to the brain. Proper function
of sensory neurons is regulated by different types of glial cells, and alterations in glial functions have
emerged as a major contributing factor in many neurodevelopmental disorders. While Schwann cells
surrounding sensory axons are…
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