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Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier model

Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Sept 2024Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025Adventitial CellAffinityAlpha VirusArthritisAssayAstrocytesAstrocytusAstrogliaAttenuatedBBB crossingBindingBioassayBiological AssayBlood - brain barrier anatomyBlood-Brain BarrierBrain InflammationCHIKVCHIKV infectionCNS Nervous SystemCaliforniaCell AttachmentCell BodyCell-Matrix AdhesionsCell-Matrix JunctionCellsCentral Nervous SystemChikungunya virusChimeraChimera organismCommunicationCrab-Eating MacaqueCrab-Eating MonkeyCynomolgus MonkeyCynomolgus macaqueDisease OutbreaksEducational process of instructingEncephalitisEndothelial CellsEnvironmentExperimental DesignsFellowshipFlavivirusFoundationsGenetic DeterminismGlycoproteinsGroup A ArbovirusesGroup B ArbovirusHemato-Encephalic BarrierHeparan SulfateHeparitin SulfateHost FactorHost Factor ProteinHumanImmuneImmunesInfectionInflammationIntegration Host FactorsInterventionLos AngelesM fascicularisM. fascicularisMacaca cynomolgusMacaca fascicularisMacaca irusMapsMediatingMedicalMiceMice MammalsModelingModern ManMolecularMolecular InteractionMurineMusNeuraxisNeurologicNeurologicalNeuropathogenesisOrthoflavivirusOutbreaksPericapillary CellPericytesPerivascular CellPhenotypePluripotent Stem CellsProgenitor CellsProteinsPublishingReceptor ProteinResearch TrainingRoleRouget CellsScienceSeminalSindbis VirusTeachingTestingTherapeuticTherapeutic ResearchTrainingUmbilical veinUniversitiesViral GeneticsVirusWorkarthriticastrocytic gliaattenuateattenuatesblood-brain barrier crossingbloodbrain barrierbloodbrain barrier crossingbrain endothelial cellbrain microvascular endothelial cellbrain vascular endothelial cellcell typecerebral endothelial cellcerebral microvascular endothelial cellcerebral vascular endothelial cellchikungunyachikungunya infectionchikungunya virus infectionchimerasgenetic determinantin vivoinfected with CHIKVinfected with chikungunyainhibitorinsightlong-tailed macaquemolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentmosquito-bornemosquitobornemultidisciplinaryneuropathologicneuropathologicalneuropathologynovelpharmacologicpluripotent progenitorprogenitor cell modelprogenitor modelprogramsreceptorsocial rolestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelstem cellstoolvirus genetics

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Description preview

PROJECT SUMMARY
Alphaviruses are mosquito-borne viruses that can cause arthritis and fatal encephalitis in humans with no
approved therapeutics. Encephalitic alphaviruses, like Sindbis (SINV) and chikungunya (CHIKV) viruses, must
cross the barriers protecting the central nervous system and therefore are neuroinvasive. The central nervous
system is…

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