grant
UNITED: Understanding neurocognitive outcomes in Type 1 diabetes: Modifiable risk and protective factors in diverse youth
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldActive Follow-upAddressAdultAdult HumanAgeAge of OnsetAmmon HornAttentionAutoimmuneBrainBrain Nervous SystemBrittle Diabetes MellitusChildChild YouthChildren (0-21)CognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunitiesCommunity Health CentersComplexContinuous Glucose MonitorCornu AmmonisCrystallizationDataDiabetes MellitusDiagnosisDisturbance in cognitionEcological momentary assessmentEligibilityEligibility DeterminationEncephalonEthnic OriginEthnicityExposure toFaceFamilyFamily memberHippocampusHomeHyperglycemiaHypoglycemiaIDDMIQ DeficitImmediate MemoryImpaired cognitionIndividualInsulin-Dependent Diabetes MellitusIntelligenceInterventionJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLeadershipLifeLiteratureLongitudinal StudiesMeasuresMetabolicMethodologyMethodsMoodsNational Institutes of HealthNeighborhood Health CenterNeural DevelopmentNeurobiologyNeurocognitiveNeurocognitive DeficitNewly DiagnosedObesityOutcomePatientsPopulation HeterogeneityPredictive FactorPredispositionPrepuberal statePreventionProductivityProtocolProtocol ScreeningProtocols documentationPubertyRaceRacesResearchRiskRisk FactorsShapesShort-Term MemorySiblingsSiteSleepSocioeconomically disadvantagedStructureSudden-Onset Diabetes MellitusSusceptibilityT1 DMT1 diabetesT1DT1DMTechnologyTestingTimeTranslational ResearchTranslational ScienceType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited States National Institutes of HealthUniversitiesWashingtonWorkYouthYouth 10-21active followupadiposityadulthoodagesbrain MR imagingbrain MRIbrain healthbrain magnetic resonance imagingcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingclinical significanceclinically significantco-morbidco-morbiditycognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive performancecognitive testingcommunity engagementcommunity level disadvantagecomorbiditycontinuous blood glucose monitorcontinuous blood sugar monitorcontinuous glucose measurementcontinuous sugar monitorcorpulencecritical perioddata collection methodologydesigndesigningdiabetesdisadvantaged communitydiverse populationsengagement with communitiesethnic minorityfacesfacialfitbitfollow upfollow-upfollowed upfollowupglycemic controlheterogeneous populationhippocampalhomeshyperglycemichypoglycemichypoglycemic episodesinsulin dependent diabetesinsulin dependent type 1intelligence quotient deficitjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidslater in lifelater lifelong-term studylongitudinal outcome studiesmalleable riskmeetingmeetingsmid lifemid-lifemiddle agemiddle agedmidlifemodifiable riskneighborhood barrierneighborhood disadvantageneighborhood-level barrierneighborhood-level disadvantageneurobiologicalneurocognitive declineneurocognitive impairmentneurodevelopmentnovelolder adultolder adulthoodpopulation diversityprepubertalprepubertyprimary outcomeprocessing speedprotective factorsracialracial backgroundracial minorityracial originrecruitresponserisk mitigationrural under servedrural underservedsecondary outcomesexsocial health determinantssocio-economicsocio-economic disadvantagesocio-economicallysocio-economically disadvantagedsocio-economically underprivilegedsocioeconomic disadvantagesocioeconomicallysocioeconomically underprivilegedsocioeconomicstranslation researchtranslational investigationtype I diabetestype one diabetesworking memoryyoungsteryouth age
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PROJECT SUMMARY
Growing evidence suggests that individuals with Type 1 diabetes mellitus (T1D) are at risk for cognitive
dysfunction over time, with approximately 28% of middle-aged adults with T1D and 48% of older adults with T1D
meeting criteria for clinically significant cognitive impairment. Our team and others have shown early appearing…
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