grant
Understanding Treg-mediated modulation of microglia in breast cancer brain metastasis
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 30 Sept 2025Deadline 29 Sept 2029
NIHUS FederalResearch GrantFY20255' ribonucleotide phosphohydrolase5'-AMP Nucleotidase5'-N'Tase5'-NT5'-Nucleotidase5'-Nucleotidase PhosphoribolaseAMP PhosphataseAblationAdenosineAdenosine A3 ReceptorAdenosine ReceptorsAdenylate PhosphataseAmericanAnatomic SitesAnatomic structuresAnatomyAntigen PresentationAntitumor ResponseAssayAutoimmune StatusAutoimmunityBioassayBiological AssayBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain MetastasisBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBreast CancerBreast Cancer PatientBreast MetastasisBreast Tumor PatientCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD73 AntigensCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCNS Nervous SystemCancersCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCentral Nervous SystemClinicalCo-cultureCocultivationCocultureCoculture TechniquesCytidylate PhosphataseDataDevelopmentDiagnosisDiseaseDisease ProgressionDisorderDisseminated Malignant NeoplasmEcto-5'-NucleotidaseEncephalonEnvironmentGeneral Prognostic FactorGenerationsHemato-Encephalic BarrierHigh PrevalenceHortega cellIMP NucleotidaseIMP PhosphataseIMPaseImmuneImmune responseImmunesImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapeutic agentImpairmentIn VitroInfiltrationInflammatoryInosinate PhosphataseIntermediary MetabolismLYT3LinkMacrophageMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMediatingMetabolic ProcessesMetabolismMetastatic CancerMetastatic Malignant NeoplasmMetastatic Neoplasm to the BrainMetastatic Tumor to the BrainMetastatic breast cancerMetastatic malignant neoplasm to brainMiceMice MammalsMicrogliaMurineMusMφNeuraxisP1 PurinoceptorsPathologyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeripheralPhenotypePlayPopulationPrognosisPrognostic FactorPrognostic/Survival FactorPurinergic P1 ReceptorsPyrimidine 5'-NucleotidaseReceptor SignalingRegulatory T-LymphocyteReportingRoleSubcellular ProcessT cell infiltrationT-Cell DepletionT-cell depletion therapyT-lymphocyte depletion therapyT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTeff cellTestingTherapeuticThymidine PhosphataseTreatment EfficacyTregTumor ImmunityTumor PromotionUnited StatesUridylate 5'-NucleotidaseWomanWorkabnormal brain functionantagonismantagonistanti-tumor immune responseanti-tumor immunityanti-tumor responseantitumor immunitybloodbrain barrierbrain dysfunctionbrain impairmentbrain micrometastasisbreast cancer metastasiscancer immunitycancer progressiondetermine efficacydevelopmentaldysfunctional braineffector T cellefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacygitter cellhost responseimmune drugsimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune-based therapeuticsimmunologic reactivity controlimmunologic therapeuticsimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunotherapeuticsimmunotherapy agentimprovedimproved outcomein vivoindividuals with breast cancerintervention efficacymalignancymalignant breast tumormesogliametastatic breast tumormetastatic mammary cancermetastatic mammary tumormicroglial cellmicrogliocyteneoplasm progressionneoplasm/cancerneoplastic progressionnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypatient oriented outcomespatients with breast cancerperivascular glial cellperson with breast cancerpreventpreventingprogramsregulatory T-cellsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesystemic autoimmunitytherapeutic efficacytherapeutic targettherapy efficacytumortumor progressiontumors in the brain
Description preview
PROJECT SUMMARY
Metastatic brain tumors represent the most common form of malignancy in the central nervous
system. In women with metastatic breast cancer, up to 35% of patients will suffer from brain
metastasis and will have little to no therapeutic options to treat them. Current treatments are often
complicated by the protected environment of…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click