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Understanding the structural, functional, and prognostic implications of cortical excitability in Alzheimer's disease

Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 15 May 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years oldAD dementiaAD related dementiaADRDAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaBiometricsBiometryBiostatisticsBirthBrainBrain Nervous SystemChildChild YouthChildren (0-21)ClinicalClinical ResearchClinical StudyClinical TrialsCognitiveCollectionDataData AnalysesData AnalysisDementiaDiagnosisDiseaseDisease ProgressionDisorderDrugsEEGElectroencephalogramElectroencephalographyEncephalonFailureFamilyFirst BirthsFunctional MRIFunctional Magnetic Resonance ImagingFundingFutureGoalsInvestigatorsLinkManuscriptsMeasurementMeasuresMedicationMentorshipMissionMotor CortexNational Institutes of HealthNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronsOutcomeParietal LobeParticipantParturitionPathogenesisPatient RecruitmentsPharmaceutical PreparationsPreventionPrimary Senile Degenerative DementiaProductivityPrognostic MarkerPublic HealthResearch PersonnelResearchersRestSiteSpeedTechniquesTestingThickThicknessTranscranial magnetic stimulationUnited StatesUnited States National Institutes of Healthcareercareer developmentcohortdata interpretationdrug/agentexperiencefMRIhuman diseaseimprovedinnovateinnovationinnovativekidsneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuronalneuronal degenerationneurophysiologicalneurophysiologynew markernon-invasive brain stimulationnovelnovel biomarkernovel markerparietal cortexparticipant recruitmentprimary degenerative dementiaprognosticprognostic biomarkerprognostic indicatorresponserestorationsenile dementia of the Alzheimer typesynapse functionsynaptic functiontoolyoungster

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PROJECT SUMMARY/ABSTRACT
Alzheimer’s disease (AD) is the leading cause of dementia and is increasing worldwide, yet currently
lacks effective disease-modifying treatments. One possible missing link is a failure to restore normal neuronal
function. Measures of cortical excitability using transcranial magnetic stimulation with…

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