grant
Understanding the mechanisms involved in HIV-1 CNS latency
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Sept 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAnatomic SitesAnatomic structuresAnatomyAnti-Retroviral AgentsAstrocytesAstrocytusAstrogliaBasal Transcription FactorBasal transcription factor genesBiologic ModelsBiologicalBiological ModelsBiopsyBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood VesselsBlood monocyteBlood-Brain BarrierBody TissuesBrainBrain Nervous SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCNS Nervous SystemCNS infectionCell BodyCell LineageCellsCentral Nervous SystemCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderDNAData SetDeoxyribonucleic AcidDevelopmentDrugsEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionHIVHIV-1HIV-IHIV1Hemato-Encephalic BarrierHortega cellHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Immune systemIn VitroIndividualInfectionInfiltrationInterpretable MLInterpretable machine learningKnowledgeLAV-HTLV-IIILong Terminal RepeatsLymphadenopathy-Associated VirusLymphatic TissueLymphoid TissueMacrophageMaintenanceMarrow monocyteMedicationMethylationMicrogliaModalityModel SystemModelingModern ManMucosaMucosal TissueMucous MembraneMyelogenousMyeloidMyeloid CellsMφNerve CellsNerve UnitNetwork-basedNeural CellNeuraxisNeurocyteNeuronsNeuropathogenesisOrganoidsPathogenesisPathway interactionsPeripheralPersonsPharmaceutical PreparationsPhysiologicPhysiologicalProcessProteinsRNA ExpressionRestRoleSignal PathwayStructureSystemSystems BiologyT4 CellsT4 LymphocytesTherapeuticTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransmissionVariantVariationViralViral LatencyViral reservoirVirusVirus LatencyVirus reservoirVirus-HIVanti-retroviralantiretroviral therapyantiretroviral treatmentastrocytic gliabiologicbloodbrain barriercell typedevelopmentaldrug/agentepigenetic regulationepigeneticallyepigenomicsexplainable MLexplainable machine learninggitter cellhistone modificationhumanized micehumanized mouseimprovedin vivoinnovateinnovationinnovativelarge data setslarge datasetslatency/reactivationlatent virus activationlymph organlymphatic organlymphoid organmesogliamicroglial cellmicrogliocytemonocytemouse modelmulti-modal datamulti-modal datasetsmultimodal datamultimodal datasetsmurine modelneuronalnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetnucleic acid long terminal repeatoverexpressoverexpressionpathwayperivascular glial cellpromoterpromotorreactivation from latencyreconstitutereconstitutionscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolethree dimensionaltranscription factortranscriptomicstransmission processvascular
Description preview
In people with HIV (PWH), infected cells persist in several tissue compartments, including
brain and lymphoid organs, and can remain indefinitely during combination antiretroviral therapy
(cART). This persistence is due to the ability of the virus to establish a state of latency in cells,
where the proviral DNA remains transcriptionally silent for…
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