grant
Understanding the mechanisms driving emergence of atypical age-associated thymic epithelial cells
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 31 Dec 2025Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AgeAgingAndrogen ReceptorAntigen Defined by Monoclonal Antibody AUAIAntigensAtrophicAtrophyAttenuatedAutoimmune StatusAutoimmunityAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBioinformaticsCancersCell BodyCell Communication and SignalingCell ProtectionCell SignalingCellsCellular Immune FunctionChemicalsClonalityCuesCytoprotectionDataEducationEducational aspectsEpCAMEpithelial Cellular Adhesion MoleculeEpitheliumEstrogen ReceptorsFellowshipGA733-2Gastrointestinal Tumor-Associated Antigen 2, 35-KD GlycoproteinGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGeneticGoalsGonadal Steroid HormonesGrowthGrowth AgentsGrowth FactorGrowth SubstancesImmuneImmunesImmunityIntracellular Communication and SignalingInvestigatorsKineticsM4S1MIC18Malignant NeoplasmsMalignant TumorMediatorMembrane Component, Chromosome 4, Surface Marker 1MolecularNGS MethodNGS systemOrganPathway interactionsPeripheralPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPopulationProcessProteinsProteins Growth FactorsResearch PersonnelResearchersRoleSelf ToleranceSex HormonesSex Steroid HormonesSignal TransductionSignal Transduction SystemsSignalingSocial Support SystemSourceStromal CellsStructure of thymic cortexSupport SystemT-Cell DevelopmentT-Cell OntogenyT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-cell receptor repertoireTACSTD1TACSTD1 geneTCR repertoireTestingTherapeuticThymic epithelial cellThymusThymus CortexThymus GlandThymus ProperThymus Reticuloendothelial SystemTissue GrowthTrainingTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceTumor-Associated Calcium Signal Transducer 1Vaccinesadaptive immunityage associatedage associated declineage associated functional declineage correlatedage dependentage dependent declineage dependent functional declineage induced loss of functionage linkedage relatedage related declineage related functional declineage specificage-related loss of functionaged miceaged mouseagesaging associated functional declineaging induced functional declineaging related functional declineattenuateattenuatesattenuationautoreactive T cellbiological signal transductioncell typeconstrictioncytoprotectivedecline with agedoctoral studentdrivingelderly miceelderly patientemerging pathogenexperimentexperimental researchexperimental studyexperimentsfunctional decline due to agingfunctional decline with agefunctional decline with agingfunctional lossfunctional loss with aginggonadal steroidsimaging approachimaging based approachimmune functionimmunogeninnovateinnovationinnovativelife spanlifespanmalignancyneoplasm/cancernew drug targetnew druggable targetnew markernew pathogennew pharmacotherapy targetnew therapeutic targetnew therapy targetnext gen sequencingnext generation sequencingnextgen sequencingnovelnovel biomarkernovel drug targetnovel druggable targetnovel markernovel pathogennovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetold miceolder patientontogenypathogenpathwaypharmacologicpodoplaninpre-clinicalpreclinicalresponseself-reactive T cellsex steroidskillssocial rolethymus derived lymphocytetooltranscription factor
Description preview
The goal of this proposal is to define the cellular sources of atypical age associated thymic epithelial cells (aaTECs) and uncover molecular pathways that promote their emergence with aging. The thymus is a critical primary immune organ responsible for giving rise to a diverse, yet self-tolerant, T cell pool. This critical T cell development…
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