grant
Understanding the Impact of Micro- and Nanoplastics on Preterm Birth
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20261st trimesterAddressAffectAirAnimal ModelAnimal Models and Related StudiesAnimalsAutomobile DrivingAutoregulationBacteriaBiological MarkersBirthBloodBlood Reticuloendothelial SystemBody FluidsBody TissuesCausalityCell BodyCellsCells Placenta-TissueCellular Immune FunctionChemotactic CytokinesChloroethylene HomopolymerChloroethylene PolymerChronologic Fetal MaturityClassificationClinicalCohort StudiesCord BloodDataDetectionDysfunctionEarly Placental PhaseEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental PollutantsEnvironmental Risk FactorEnvironmental ToxinEquilibriumEthene, chloro-, homopolymerEtiologyExposure AssessmentExposure toFetal AgeFetal TissuesFirst Pregnancy TrimesterFirst TrimesterFoodFood PackagingFosteringFoundationsFunctional disorderFutureGC MSGCMSGas-Liquid-Mass Spectrometry ChromatographyGene ExpressionGestationGestational AgeGuidelinesHealth Care CostsHealth CostsHistopathologyHomeostasisHomologous Chemotactic CytokinesHumanHuman FigureHuman bodyHydrogen OxideImmuneImmune infiltratesImmunesIn VitroInfantInflammationInflammatoryInflammatory ResponseIntercrinesKnowledgeLifeMachine LearningMapsMass FragmentographiesMass FragmentographyMass-Gas Chromatography SpectrometryMass-Gas Chromatography Spectrum AnalysisMaternal and Child HealthMaternal-Fetal ExchangeMeasuresMedical DeviceMethodsMicroplasticsModelingModern ManMolecularMorbidityNormal PlacentomaOstamerOutcomeOxidative StressParturitionPathologyPatternPellethanePerinatalPeripartumPhysiological HomeostasisPhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePlasticsPolychloroethylenePolyethylene TerephthalatesPolyisocyanatesPolymersPolystyrenesPolystyrolPolyurethanesPolyvinyl ChloridePopulationPostpartum PeriodPregnancyPremature BirthPrematurely deliveringPreterm BirthPreventionPublic HealthPublishingReportingResearchResearch SpecimenRiskRisk FactorsRoleSIS cytokinesSamplingSpecimenSymptomsSystemSystematicsTestingTimeTissuesToxic Environmental AgentsToxic Environmental SubstancesTransplacental ExposureUmbilical Cord BloodUrineVinyl Chloride PolymerVulnerable PopulationsWateradvanced analyticsadverse pregnancy outcomeat-risk pregnanciesbalancebalance functionbio-markersbioaccumulationbiologic markerbiomarkercausationchemoattractant cytokinechemokineco-exposuresco-occurring exposurecohortcohort research studycohort surveycombined exposurecomplex exposureconcurrent exposureconsumer productcytokinedata integrationdesigndesigningdisease causationdrivingenvironmental contaminantenvironmental riskenvironmental toxicantevidence baseexposed human populationexposure analysisexposure evaluationexposure measurementexposure mixtureexposure profilingexposure surveyexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfetalfetal cord bloodfetus tissuehigh definitionhigh-resolutionhuman exposurehuman tissueimmune cell infiltrateimmune functionimmune microenvironmentimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentinflammation markerinflammatory markerinnovateinnovationinnovativeinsightion trap mass spectrometrymachine based learningmalleable riskmass fragmentometrymaternal-fetal interfacemixed exposuremodel of animalmodifiable riskmortalitynano particlenano plasticsnano-sized particlenanoparticlenanosized particlenew markernovel biomarkernovel markerparticlepathophysiologypolycarbonatepolymerpolymericpolyvinylchloridepost-partumpredictive signaturepremature childbirthpremature deliverypreterm deliveryrandom forestrisk mitigationsimultaneous exposuressocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssub micronsubmicronsuccesssupervised learningsupervised machine learningsystemic inflammationsystemic inflammatory responsetoxicanttumor immune microenvironmenttumor-immune system interactionsvinylchloride polymervulnerable groupvulnerable individualvulnerable people
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Description preview
Preterm birth (PTB) affects 10% of pregnancies globally, with rates rising 12% between 2014-2022, incurring
healthcare costs exceeding $25 billion annually in the US alone. While inflammation is a known trigger of PTB,
the environmental factors driving this inflammatory response remain poorly understood. A critical knowledge gap
exists in…
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