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Understanding Plasmodium falciparum's multidrug resistance protein through the characterization of a novel antimalarial class.

Organization UNIVERSITY OF GEORGIALocation ATHENS, UNITED STATESPosted 1 May 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025ABC Transport ProteinABC Transporter ProteinABC TransportersABC20ABCB1ABCB1 geneATP-Binding Cassette TransportersAddressAffectAnti-malarial drug resistanceAnti-malarial drug resistantAnti-malarialsArtemisininsAzidesBiologyCessation of lifeCharacteristicsChemicalsClinicalCombined Modality TherapyCopy Number PolymorphismCytosolDNA mutationDeathDevelopmentDiazirineDiazomethaneDiseaseDisorderDrug DesignDrug ModulationDrug resistanceDrug usageDrugsFluorescence Light MicroscopyFluorescence MicroscopyGP170Gene AlterationGene AmplificationGene MutationGenesGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGoalsHemoglobinIn VitroInvestigatorsKnock-outKnockoutLibrariesLigandsLysosomesMDR-1MDR1MDR1 ProteinMalariaMediatingMedicationMedicineMentorshipMolecularMolecular TargetMultidrug Resistance 1Multidrug Resistance Gene-1Multidrug Resistance Gene-1sMultidrug Resistance ProteinsMultidrug Resistant ProteinsMultimodal TherapyMultimodal TreatmentMutationOrganellesOutcomeP falciparumP-GPP-GlycoproteinP-Glycoprotein 1 GeneP. falciparumP.falciparumPGY-1 ProteinPGY1PaludismParasite resistanceParasitesParasitic DiseasesPersonsPharmaceutical PreparationsPlasmodiumPlasmodium InfectionsPlasmodium falciparumPopulationPredispositionProteinsProteomicsPumpQualifyingRegimenResearchResearch PersonnelResearchersResistanceResistance developmentResistant developmentScientistSingle Base PolymorphismSingle Nucleotide PolymorphismSurfaceSusceptibilityTechniquesTestingTrainingUniversitiesVacuoleValidationWorkacquired drug resistanceanti-malarial agentsanti-malarial drugsanti-malarial resistancearteannuinartemisininechemoproteomicschemotherapycombination therapycombined modality treatmentcombined treatmentcopy number variantcopy number variationdesigndesigningdeveloping resistancedevelopmentaldiazo-methanedrug discoverydrug resistantdrug sensitivitydrug usedrug/agentexperiencegene defectgenome mutationimprovedinsightknock-downknockdownmulti-modal therapymulti-modal treatmentmutant allelenatural gene amplificationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetparasite resistantpolymorphismpreventpreventingqinghaosuquing hau sauquinghaosuresistance in parasiteresistance mechanismresistance strainresistance to Drugresistance to Parasiteresistance to anti-malarial drugresistantresistant mechanismresistant parasiteresistant strainresistant to Drugresistant to Parasiteresistant to anti-malarial drugresponsescreeningscreeningssingle nucleotide variantundergradundergraduateundergraduate studentvalidationsvirtual

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Description preview

PROJECT SUMMARY
Malaria is a deadly disease that affects nearly half the world’s population. In 2021, there was an estimated
619,000 deaths due to malaria. Currently, the front-line treatment for uncomplicated malaria is Artemisinin-based
Combination Therapies (ACTs), where an artemisinin-related compound is paired with a slower acting partner…

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