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Understanding Metabolic Interplay in a Human iPSC Model of Diabetic Cardiomyopathy
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2024Deadline 31 Jul 2025 ⚠️
NIHUS FederalResearch GrantFY20252-dimensional3-D3-Dimensional3DASCVDAblationAccelerationAdult-Onset Diabetes MellitusAffectAgeAtherosclerosisAtherosclerotic Cardiovascular DiseaseAutopsyBindingBinding ProteinsBiologicalBiomedical ResearchBlood VesselsBody TissuesCalciumCardiacCardiac Muscle CellsCardiac MyocytesCardiocyteCardiovascularCardiovascular AgentsCardiovascular Body SystemCardiovascular DiseasesCardiovascular DrugsCardiovascular ModelsCardiovascular Organ SystemCardiovascular systemCause of DeathCell BodyCell Communication and SignalingCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeClinical TrialsCo-TransportersCommunitiesComplexConditioned Culture MediaConditioned MediumCoupledD-GlucoseDeathDevelopmentDextroseDiseaseDisorderDrugsDysfunctionEndothelial CellsExcretory functionFibroblastsFunctional disorderGeneticGlucoseHeartHeart Muscle CellsHeart VascularHeart failureHeart myocyteHospital AdmissionHospitalizationHumanHypertensionIndividualIntracellular Communication and SignalingInvestigatorsIsotopesKetosis-Resistant Diabetes MellitusKidneyKidney Urinary SystemKnock-outKnockoutLC/MSLigand Binding ProteinLigand Binding Protein GeneMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaturity-Onset Diabetes MellitusMeasurementMeasuresMedicationMetabolicMetabolic DiseasesMetabolic DisorderMitochondriaModelingModern ManMolecularMolecular InteractionMyocardialNIDDMNa elementNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusOxygen ConsumptionPathogenesisPathologicPathologyPathway interactionsPatientsPeptidesPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePhysiopathologyPopulationPreclinical TestingProliferatingProtective AgentsProtective DrugsProtein BindingProtein CleavageProteinsProteolysisProteomicsProtocolProtocols documentationPublic HealthResearchResearch PersonnelResearchersResolutionRespirationSamplingSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSodiumStable Diabetes MellitusStrains Cell LinesSubcellular ProcessSystemSystems BiologyT2 DMT2DT2DMTherapeuticThesaurismosisTissuesTrainingType 2 Diabetes MellitusType 2 diabetesType 2 diabeticType II Diabetes MellitusType II diabetesType II diabeticValidationVascular Hypertensive DiseaseVascular Hypertensive DisorderVentricle RemodelingVentricular Cardiac RemodelingVentricular Myocardial RemodelingVentricular Remodelingabsorptionadult onset diabetesagesatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebiobankbiologicbiological signal transductionbiorepositorybound proteincardiac failurecardiac tissue engineeringcardiomyocytecardioprotectantcardioprotectioncardioprotectivecardiovascular disordercardiovascular riskcardiovascular risk factorcell typecirculatory systemcultured cell linedesigndesigningdevelopmentaldiabeticdiabetic cardiomyopathydiabetic cardiopathydiabetic cardiopathy diseasediabetic cardiopathy disorderdiabetic cardiovascular diseasediabetic cardiovascular disorderdiabetic patientdirected differentiationdisease phenotypedrug/agentengineered heart tissueethnic diversityethnically diverseexcretionfascinateglucose uptakeglycemic controlhiPSChigh blood pressurehuman derived modelhuman derived systemhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman like modelhuman like platformhuman like systemhuman specific modelhuman specific systemhuman-based biological modelshuman-based modelhuman-based nonanimal modelshuman-based platformhuman-based researchhuman-based systemhuman-based toolshuman-focused researchhyperpiesiahyperpiesishypertensive diseasehypertensive disorderiPSiPSCiPSC technologyiPSCsin vitro Modelinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell technologyinducible pluripotent cellinducible pluripotent stem cellinhibitorinnovateinnovationinnovativeinsightketosis resistant diabetesknock-downknockdownliquid chromatography mass spectrometrymaturity onset diabetesmetabolic phenotypemetabolism disordermetabolism measurementmetabolomicsmetabonomicsmetabotypemigrationmitochondrialmonolayermortalitymyocardial remodelingnecropsynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypathwaypatient retentionpharmaceuticalpostmortempre-clinical testingpreventpreventingprogenitor cell modelprogenitor modelprotective effectrenalresolutionsrespiratory mechanismsexstem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelsymporterthree dimensionaltissue culturetooltwo-dimensionaltype 2 DMtype II DMtype two diabetesvalidationsvascular
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Project Summary
Type 2 diabetes (T2D) is a leading cause of death nationwide, with 65% of mortality due to cardiovascular
disease. The term “diabetic cardiomyopathy (T2DCM)” refers to a condition with adverse myocardial remodeling
in the absence of hypertension and vascular pathology. Although T2D and CVD are tightly intertwined, we lack
a deeper…
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