grant
Understanding metabolic and regulatory control of antibiotic production in filamentous actinobacteria
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 5 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20252,5-Diaminopentanoic AcidActinobacteriaActinobacteria classActinomycetesAnti-Cancer AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAreaCancer DrugCellular ExpansionCellular GrowthChemicalsClinicalDedicationsDevelopmentFamilyGene ClusterGene TranscriptionGenetic PolymorphismGenetic TranscriptionGenomeGenomicsGiftsGoalsHealthHigh G+C Gram-Positive BacteriaHumanImmunotherapeutic agentIntermediary MetabolismKnowledgeLinkMedicineMetabolicMetabolic ControlMetabolic ProcessesMetabolismMethodologyMicrobial PhysiologyMiscellaneous AntibioticModelingModern ManNatureNeoplastic Disease Chemotherapeutic AgentsNucleotidesOrganismOrnithinePathway interactionsPeptidesPhenotypeProductionRNA ExpressionResearchSolidSourceSurfaceTherapeuticTranscriptionTumor-Specific Treatment AgentsWorkanti-cancer drugcell growthdevelopmentaldrug discoverydrug-like chemicaldrug-like compounddrug-like moleculeempowermentimmune drugsimmune-based therapeuticsimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentinsightliving systemmultidisciplinarynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypolymorphismprogramspromoterpromotorscaffoldscaffoldingtrait
Description preview
Project Summary
Bioactive molecules from nature are valuable templates for essential medicines. Filamentous actinobacteria are
gifted producers of such molecules and rank among the richest sources yet discovered. They produce >50% of
clinical antibiotics, plus numerous other medicines including immunotherapeutics and anticancer agents. These…
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