grant
Understanding Mechanisms of Organic Reactions and Processes through Imaging
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 20 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AreaBehaviorCarbonCatalysisChemicalsChemistryCouplingDataDevelopmentDiseaseDisorderDrug Synthesis and ChemistryEmulsionsFLIM imagingFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyFoundationsHydrogen OxideImageImaging DeviceImaging InstrumentImaging ToolLaboratoriesLeadLigandsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMetalsMethodsMissionModelingModernizationNIGMSNMR SpectrometerNMR SpectroscopyNational Institute of General Medical SciencesOrganic ChemistryOrganic SynthesisPb elementPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePowder dose formPowdersPreparationProcessProductionPublic HealthPublicationsReactionReagentRecyclingResearchRouteScientific PublicationSurfaceSystemTechniquesTherapeuticTherapeutic AgentsTransition ElementsWateranalytical toolaqueouscatalystcold temperaturedevelopmentaldrug discoverydrug synthesisdrug-like chemicaldrug-like compounddrug-like moleculeexperimentexperimental researchexperimental studyexperimentsfluorescence life-time imagingfluorescence life-time imaging microscopyfluorescence lifetime imagingfluorescence lifetime imaging microscopyheavy metal Pbheavy metal leadhuman diseaseimage-based methodimagingimaging agentimaging methodimaging modalityinnovateinnovationinnovativeinsightlow temperaturemethod developmentmicroscope imagingmicroscopic imagingmicroscopy imagingmultidisciplinarynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynuclear magnetic resonance spectroscopypharmaceuticalpreparationssuccesssurfactanttransition metal
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Project Summary
A mechanistic understanding of reactivity has enabled the development of nearly all modern synthetic organic
chemistry, which has in turn revolutionized the discovery and production of therapeutics to treat human diseases.
Yet, traditional ensemble analytical tools for investigating mechanisms, like NMR spectroscopy and mass…
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