grant
Understanding Mechanisms Driving Poor Outcomes in Women with Dermatomyositis
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 5 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AffectAntioxidantsAryl-dialkyl PhosphataseArylalkylphosphataseArylesteraseAryltriphosphataseAryltriphosphate dialkylphosphohydrolaseAutoantibodiesAutoimmuneAutoimmune DiseasesAutomobile DrivingAwarenessBiochemicalBiological MarkersBiopsyBlood SerumBlood VesselsCAT scanCT X RayCT XrayCT imagingCT scanCaliforniaCaucasian FemalesCaucasian WomenChronicCommunitiesCommunity PhysicianComputed TomographyDataDermatomyositisDermatopolymyositisDiagnosisDiagnosticDiseaseDisease OutcomeDisease ProgressionDisorderDisproportionate number of menDisproportionately impacts malesDisproportionately in menDysfunctionEarly DiagnosisEarly treatmentEducationEducational aspectsEsterase B1Esterase E4EvaluationExanthemExanthemaFailureFibrosing AlveolitisFunctional disorderGeneral PopulationGeneral PublicGoalsHDLHDL LipoproteinsHealth Care SystemsHeavy LipoproteinsHigh Density LipoproteinsHistologicHistologicallyHomocysteine Thiolactone HydrolaseIGIVIV ImmunoglobulinsIVIGImage data archiveImmuneImmune globulin IVImmunesImpairmentIncidenceInflammatoryInflammatory Muscle DiseasesInflammatory MyopathyInterstitial Lung DiseasesIntravenous AntibodiesIntravenous IGIntravenous Immune GlobulinIntravenous ImmunoglobulinsKnowledgeLungLung Respiratory SystemLung Tissue FibrosisLung damageMedicineMicrovascular DysfunctionMolecularMonitorMorbidityMorbidity - disease rateMuscle WeaknessMuscular WeaknessMyositisOPA AnhydraseOPH EnzymeOrganOrganophosphorus Acid AnhydraseOrganophosphorus Acid AnhydrolaseOrganophosphorus Acid HydrolaseOrganophosphorus HydrolaseOrphan DiseaseOutcomeOxidative StressPON1Paraoxon esteraseParaoxonaseParaoxonase 1PathogenesisPathogenicityPathway interactionsPatient ParticipationPatient RecruitmentsPatientsPatternPerfusionPersonsPhysiciansPhysiopathologyPirimiphos-methyloxon esterasePlayPolymyositis-DermatomyositisPrevalenceProteinsPublishingPulmonary FibrosisRadiographyRare DiseasesRare DisorderRashRegistriesReportingResearchRoentgenographyRoleScoring MethodSerumSkin RashSpecialtySyndromeSystemic SclerodermaSystemic SclerosisTomodensitometryUnited StatesWhite FemalesWhite WomenWomanWorkX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyalpha-Lipoproteinsaryldialkylphosphataseautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodybio-markersbiologic markerbiomarkerbiomedical referral centerblack femaleblack womencase-basedcatscancohortcompare treatmentcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographydeath riskdiffuse interstitial pulmonary fibrosisdisproportionately affects malesdisproportionately affects mendisproportionately concentrated among mendisproportionately distributed among mendisproportionately higher among mendisproportionately impacts mendisproportionately occurs in mendrivingearly detectionearly therapyethnic minority groupethnic minority individualethnic minority peopleethnic minority populationexperiencefemale outcomesfibrosis in the lungidiopathic pulmonary fibrosisimage archival systemimage archiveimage libraryimage repositoryimaging repositoryimprovedindexinginsightlipid mediatorlung fibrosislung injurymale biasmale predominancemedical specialtiesmenmen disproportionately diagnosedmen disproportionately experiencemen experience disproportionate ratesmicrovascular complicationsmicrovascular diseasemortalitymortality risknew approachesnon-contrast CTnoncontrast CTnoncontrast computed tomographynovelnovel approachesnovel strategiesnovel strategyorphan disorderoutcomes among femalesoutcomes among womenoutcomes in femalesoutcomes in womenoutreachparticipant recruitmentpathophysiologypathwaypatient centeredpatient orientedpicture archiveplacebo control trialplacebo controlled trialpredominantly affecting menpreventpreventingprogressive systemic sclerosispulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryracial minority groupracial minority individualracial minority peopleracial minority populationradiological imagingrecruitreferral centerresponse to therapyresponse to treatmentself reactive antibodysmall vessel diseasesocialsocial roletargeted biomarkertargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapeutic targettherapy responsetranscriptomicstreatment comparisontreatment guidelinestreatment responsetreatment responsivenessvascularvascular inflammationwebsite developmentwomen's outcomes
Description preview
Project Summary
Dermatomyositis (DM) is a rare autoimmune disease, affecting predominantly women, particularly
Black women, which associates with marked disease-related morbidity as well as a 10-fold increased risk of
death. DM is characterized by muscle weakness and skin rashes, but over 70% of patients may also develop
interstitial lung disease…
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