grant
Understanding hematopoietic stem and progenitor cell diversity during ontogeny
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBloodBlood CellsBlood DiseasesBlood Precursor CellBlood Reticuloendothelial SystemBrachydanio rerioCell BodyCell LineageCellsCharacteristicsClinicalComplexDanio rerioDataData SetDevelopmentEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEndothelial CellsEndotheliumGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGoalsGrowthHSC differentiationHSC nicheHSC quiescenceHSC regenerationHSC self-renewalHealthHematologic CancerHematologic DiseasesHematologic MalignanciesHematologic NeoplasmsHematological DiseaseHematological DisorderHematological MalignanciesHematological NeoplasmsHematological TumorHematopoiesisHematopoieticHematopoietic CancerHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic stem cellsHumanImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIn Situ HybridizationIn VitroKnowledgeLineage TracingLymphoidLymphoid CellMalignant Hematologic NeoplasmMapsModern ManMolecularMultipotent Stem CellsPeripheral Blood CellPopulationPopulation CharacteristicsProcessProgenitor CellsPropertyProtocolProtocols documentationRegenerative capacityReplacement TherapyRoleSpecific qualifier valueSpecifiedStem Cell DevelopmentSystemThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissue GrowthTranscription Factor Proto-OncogeneTranscription factor genesZebra DanioZebra FishZebrafishadulthoodblood cell formationblood cell progenitorblood disorderblood progenitorblood stem cellblood stem cell nicheblood stem cell quiescenceblood stem cell regenerationblood stem cell self-renewalblood-forming stem cellcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingdevelopmentalexperimentexperimental researchexperimental studyexperimentsgene signaturesgenetic signaturehematopoietic differentiationhematopoietic progenitorhematopoietic progenitor cell differentiationhematopoietic progenitor cell self-renewalhematopoietic progenitor differentiationhematopoietic progenitor nichehematopoietic stem cell differentiationhematopoietic stem cell nichehematopoietic stem cell quiescencehematopoietic stem cell regenerationhematopoietic stem cell self-renewalhematopoietic stem progenitor cellhemogenic endotheliumhemopoietichemopoietic progenitorhemopoietic stem cellin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivolymphocyte precursorlymphocyte progenitorlymphocyte stem celllymphoid precursorlymphoid progenitorslymphoid stem cellmultipotent progenitormultipotent progenitor cellnovelontogenyprogenitorprogenitor biologyprogenitor cell biologyprogenitor cell developmentprogenitor cell fateprogenitor cell markersprogenitor cell poolprogenitor cell populationprogenitor developmentprogenitor fateprogenitor markersprogenitor poolprogenitor populationprogenitor stem cell markersregeneration abilityregeneration capacityregeneration of blood stem cellsscRNA sequencingscRNA-seqself - renewal in hematopoietic stem cellsself renewing cellself-renewself-renewalsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporalstemstem and progenitor biologystem and progenitor cell developmentstem and progenitor cell fatestem and progenitor cell populationstem cell biologystem cell biomarkersstem cell fatestem cell markersstem cell poolstem cell populationstem cellstranscription factor
Description preview
PROJECT SUMMARY
The goal of this project is to understand hematopoietic stem and progenitor cell diversity
during ontogeny. Hematopoietic stem cells (HSCs) are self-renewing, multipotent stem cells that
maintain the entire blood system through a process called hematopoiesis. During embryogenesis,
HSCs emerge simultaneously with HSC-independent…
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