grant
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes-Texas Children's Center.
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 5 Mar 2023Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20250-11 years old19 year old19 years of age21+ years oldAdultAdult HumanAdult-Onset Diabetes MellitusAeroseb-HCAgeAlgorithmsBehavioralBeta CellBiochemicalBlackBlack raceBody CompositionBody fatCatecholaminesCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCetacortChildChild YouthChildhoodChildren (0-21)Children's HospitalClinicalCollaborationsCollectionCommunitiesComplexConceptionsCort-DomeCortefCortenemaCortisolCortisprayCortrilCountyDEXADNA MethylationDXADepositDepositionDermacortDeteriorationDevelopmentDiagnosisDiseaseDisease OutcomeDisorderDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryDysfunctionEarly identificationEldecortEndocrine Gland SecretionEnrollmentEnsureEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEvolutionFailureFamilyFatsFatty acid glycerol estersFunctional disorderGeneticGestational DiabetesGestational Diabetes MellitusGoalsGonadal Steroid HormonesGrowth AgentsGrowth FactorGrowth SubstancesGrowth and DevelopmentGrowth and Development functionHPA axisHealth InsuranceHealth SurveysHepaticHispanicHormonalHormonesHydrocortisoneHydrocortoneHytoneIndividualInflammationInsulin CellInsulin ResistanceInsulin Secreting CellInterventionInvestigationInvestigatorsKetosis-Resistant Diabetes MellitusKnowledgeLatinoLongitudinal SurveysMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaturity-Onset Diabetes MellitusMeasurementMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMethodologyMethylationMissionModelingNIDDMNMR ImagingNMR TomographyNational Institutes of HealthNon-HispanicNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonhispanicNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNot Hispanic or LatinoNuclear Magnetic Resonance ImagingNutracortOGTTObesityOnset of illnessOral Glucose Tolerance TestOrganPathogenesisPathway interactionsPediatric HospitalsPhenotypePhysiologicPhysiologicalPhysiopathologyPopulationPrediabetesPrediabetes syndromePrediabetic StatePredicting RiskPredisposing FactorPredispositionPregnancy-Induced DiabetesPrevalencePreventionProcessProctocortProteins Growth FactorsPubertyResearch DesignResearch InfrastructureResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk FactorsSex HormonesSex Steroid HormonesSlow-Onset Diabetes MellitusStable Diabetes MellitusStandardizationStressStudy TypeSubcellular ProcessSurvey InstrumentSurveysSusceptibilitySympathinsT2 DMT2DT2DMTexasTherapeutic HormoneType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited States National Institutes of HealthVariantVariationVisceral fatYouthYouth 10-21Zeugmatographyabdominal adiposityabdominal fatadiposityadult onset diabetesadulthoodadverse childhood eventsadverse childhood experiencesage 19 yearsagesbalancebalance functionclinical centerclinical phenotypeco-morbidco-morbiditycohortcomorbiditycomputer based predictioncorpulencedesigndesigningdevelopmentaldiabetes pathogenesisdisease onsetdisease phenotypedisease riskdisorder onsetdisorder riskenrollenvironmental riskepigenetic biomarkerepigenetic markerepigenetic regulationepigeneticallyethnic diversityethnic minorityethnically diversefederal poverty levelforecasting riskglucose toleranceglycemic controlgonadal steroidshealth determinantshealth insurance planhigh riskhypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisimprovedindexinginnovateinnovationinnovativeinsightinsulin resistantinsulin secretioninsulin sensitivityinsulin toleranceinter-individual variabilityinter-individual variationketosis resistant diabeteskidsmaternal adipositymaternal obesitymaturity onset diabetesmembermultidisciplinarynineteen year oldnineteen years oldnovelpathophysiologypathwaypatient populationpediatricperipheral bloodpersonalized health interventionpersonalized interventionpre-diabetespre-diabeticprecision interventionsprediabeticpredict responsivenesspredict riskpredict riskspredicted riskpredicted riskspredicting responsepredicting risksprediction algorithmpredictive modelingpredictive riskpredicts riskpregnancy diabetespreventpreventingprogression riskpubertal transitionpuberty transitionracial minorityrecruitrisk predictionrisk predictionsrisk stratificationsex steroidsocialsocial factorssocial health determinantsstemstratify riskstudy designsuccesstransition out of pubertytreatment strategytype 2 DMtype II DMtype two diabetesurinaryyoungsteryouth ageβ-cellβ-cellsβCell
Description preview
Youth-onset type 2 diabetes (YO-T2D) is increasingly prevalent in parallel with the obesity epidemic, yet effective treatment and prevention strategies are limited. The physiologic increase in insulin resistance occurring during puberty, in combination with obesity-related insulin resistance, enhances the risk of T2D. Yet, it remains unclear why…
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