grant
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes - Biostatistics Research Center
Organization GEORGE WASHINGTON UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 1 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years oldActive Follow-upAddressAdolescentAdolescent YouthAdult-Onset Diabetes MellitusAgreementApproaches to preventionBehavioralBeta CellBiochemicalBiometricsBiometryBiostatisticsBusiness-Friendly AtmosphereCase Report FormCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCertificationCharacteristicsChildChild YouthChildhoodChildren (0-21)Clinical ResearchClinical StudyClinical TrialsCollaborationsCommunicationComplications of Diabetes MellitusConflict of InterestConsentCoupledCreativenessDataDeteriorationDevelopmentDevicesDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic ComplicationsDiseaseDisorderDysfunctionEnrollmentEnsureEpidemiologyEventFunctional disorderFundingFutureGenetic MaterialsGeographyGoalsHormonalIRBIRBsIncidenceInfrastructureInstitutional Review BoardsInsulin CellInsulin ResistanceInsulin Secreting CellIntentionInterventionInvestigatorsKetosis-Resistant Diabetes MellitusLaboratoriesLeadershipLogisticsManualsManuscriptsMaturity-Onset Diabetes MellitusMediatorMetabolicMethodologyMethodsMonitorMulti-center studiesMulticenter StudiesNIDDKNIDDMNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityObesity EpidemicObservational StudyOnset of illnessParticipantPathogenesisPerformancePersonsPhasePhenotypePhysiologicPhysiologicalPhysiologyPhysiopathologyPopulationPre-DMPrediabetesPrediabetes syndromePrediabetic StatePrevalencePreventative strategyPrevention approachPrevention strategyPreventive strategyPrivatizationProceduresProcessProtocolProtocols documentationPubertyPublicationsQualifyingQuality ControlRandomization trialReportingResearchResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk FactorsRuralSafetySamplingScientific PublicationSedentary behaviorSedentary life-styleSerious Adverse EventSevere Adverse EventSiteSlow-Onset Diabetes MellitusSpecific qualifier valueSpecifiedStable Diabetes MellitusStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStatistical MethodsStudy TypeSubcellular ProcessSystemT2 DMT2DT2DMTrainingTranslatingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUniversitiesValidationWashingtonYouthYouth 10-21active followupadiposityadult onset diabetesblood glucose regulationboysbusiness-friendly environmentclinical research siteclinical sitecohortcollaborative atmospherecollaborative environmentcorpulencecreativitydata exchangedata managementdata transferdata transmissiondepositorydesigndesigningdevelopmentaldiabetesdiabetes controldiabetes mellitus controldiabetes prevention programdiabetes riskdisease onsetdisorder onseteffective therapyeffective treatmentenrollepidemiologicepidemiologicalexperiencefollow upfollow-upfollowed upfollowupgirlsglucose controlglucose homeostasisglucose regulationglucose tolerancehigh riskimprovedinnovateinnovationinnovativeinsulin resistantinsulin secretioninsulin sensitivityinsulin toleranceinteractive atmosphereinteractive environmentinterdisciplinary atmosphereinterdisciplinary environmentjuvenilejuvenile humanketosis resistant diabeteskidsmalleable riskmaturity onset diabetesmeetingmeetingsmodifiable riskmultidisciplinarynovelobservational research studyobservational surveyoperationoperationspathophysiologypediatricpeer-group atmospherepeer-group environmentphase 2 studyphase II studypre-diabetespre-diabeticprediabeticpreservationpreventpreventingprimary outcomeprogramsprogression riskpsychologicpsychologicalquality assurancerandomized trialrecruitrepositoryresponsesecondary outcomesedentary lifestyleserious adverse experienceserious adverse reactionsocialstatistic methodsstatistical analysisstudy designsuccesstherapeutic targettimelinetreatment strategytype 2 DMtype II DMtype two diabetesuser-friendlyvalidationsvirtualweb sitewebsiteyoungsteryouth ageβ-cellβ-cellsβCell
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Youth-onset type 2 diabetes (YO-T2D) is increasingly prevalent in parallel with the obesity epidemic, yet effective treatment and prevention strategies are limited. The physiologic increase in insulin resistance occurring during puberty, in combination with obesity-related insulin resistance, enhances the risk of T2D. Yet, it remains…
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