grant
Understanding and Targeting Aberrant RNA Splicing in Leukemia
Organization SLOAN-KETTERING INST CAN RESEARCHLocation NEW YORK, UNITED STATESPosted 18 Aug 2025Deadline 31 Jul 2032
NIHUS FederalResearch GrantFY2025AML - Acute Myeloid LeukemiaAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAddressAffectAgammaglobulinaemia tyrosine kinaseAutomobile DrivingAwardB cell progenitor kinaseB-Cell CLLB-Cell Chronic Lymphocytic LeukemiaB-Cell Chronic Lymphogenous LeukemiaB-Cell Chronic Lymphoid LeukemiaB-Cell Lymphocytic LeukemiaB-Lymphocytic LeukemiaBiologicalBone Marrow FibrosisBruton's tyrosine kinaseCancersCell BodyCellsChronic B-Lymphocytic LeukemiaChronic Lymphatic LeukemiaChronic Lymphoblastic LeukemiaChronic Lymphocytic LeukemiaChronic Lymphogenous LeukemiaChronic Myelomonocytic LeukemiaDNA AlterationDNA Sequence AlterationDNA mutationDevelopmentDiseaseDisorderDysmyelopoietic SyndromesElderly AMLElderly Acute Myeloblastic LeukemiaFDA approvedGeneticGenetic AlterationGenetic ChangeGenetic defectGenetic mutationGranulocytic LeukemiaHairy Cell LeukemiaHematopoietic Cell TumorHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsImmunogenomicsIsoformsLaboratoriesLeadLeukemic ReticuloendotheliosisLymphoblastic LeukemiaLymphocytic LeukemiaLymphoid LeukemiaMalignant Hematopoietic NeoplasmMalignant NeoplasmsMalignant TumorMalignant lymphoid neoplasmMediatingMutationMyelocytic LeukemiaMyelodysplastic DiseaseMyelodysplastic SyndromesMyelofibrosisMyelogenous LeukemiaMyeloid DiseaseMyeloid LeukemiaMyeloid MalignancyMyeloid NeoplasmMyeloid TumorMyeloproliferative DisordersMyeloproliferative TumorsMyeloproliferative diseaseMyelosclerosisNeoplasmsNon-Lymphoblastic LeukemiaNon-Lymphocytic LeukemiaNonlymphoblastic LeukemiaNonlymphocytic LeukemiaOncogenesisPatientsPb elementPositionPositioning AttributeProductionProtein IsoformsProtein SplicingRNA SplicingReagentRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsResearchResistanceSequence AlterationSmoldering LeukemiaSomatic MutationSplicingTherapeuticTherapeutically TargetableWorkacute granulocytic leukemiaacute myeloid leukemiabiologicblood cancerbpk proteinbtk proteincancer of bloodcancer of the bloodchemoproteomicschronic lymphoid leukemiaclinical developmentdevelop therapydevelopmentaldrivingearly clinical trialearly phase clinical trialelderly Acute Myeloid Leukemiaelderly patientgain of function mutationgenome mutationgenomic alterationhairy T cell leukemiaheavy metal Pbheavy metal leadhigh riskhistiocyteinhibitorintervention developmentleukemialeukemia treatmentleukemic therapylymphatic leukemialymphogenous leukemialymphoid cancerslymphoid malignancymalignancymolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentmutantmyelodysplasiamyeloid granulocytic leukemiamyeloproliferative neoplasmmyelosisneo-antigenneo-epitopesneoantigensneoepitopesneoplasianeoplasm/cancerneoplastic growthnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyolder patientresistantsmall moleculesomatic varianttherapy developmenttranscriptomicstreatment developmenttumorigenesis
Description preview
For the past 13 years my lab has sought to understand both the genetic basis of hematopoietic malignancies
and the mechanisms through which mutations in splicing factors mediate oncogenesis. Our work on the
genetic basis of myeloid and lymphoid leukemias has led to several advances, most notably (1) the discovery
of the genetic alterations driving…
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