grant
Understanding and exploiting DNA topoisomerases in cancer biology
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Sept 2021Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Amino Acid SequenceAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsBiochemicalBiologyCancer BiologyCancer CauseCancer DrugCancer EtiologyCancer TreatmentCancersCell BodyCellsChemicalsChromatinChromosomal InstabilityChromosome InstabilityChromosomesCitric Acid CycleDNADNA DamageDNA InjuryDNA Topoisomerase IIDNA TopoisomerasesDNA Type 2 TopoisomeraseDeoxyribonucleic AcidDrug TargetingEnzyme GeneEnzymesEukaryotic DNA Topoisomerases IIEukaryotic Topoisomerases IIGeneticGoalsHuman ChromosomesKrebs CycleMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMethodologyMolecular MachinesNeoplastic Disease Chemotherapeutic AgentsOutcomePlayPrimary Protein StructureProteinsResearchRoleSiteSpecificitySupercoiled DNASuperhelical DNASupertwisted DNATCA cycleTopo IITopoisomeraseTopoisomerase IITricarboxylic Acid CycleTumor-Specific Treatment AgentsType II DNA TopoisomerasesVariantVariationWorkanti-cancer druganti-cancer therapycancer cellcancer therapycancer-directed therapydrug actiongenetic informationgenome integritygenomic integrityimprovedinnovateinnovationinnovativemalignancymutantneoplasm/cancerprotein sequencesocial role
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ABSTRACT
The appropriate control of DNA topology has a major impact on the stability and flow of
genetic information. The present application focuses on type II DNA topoisomerases,
molecular machines that modulate DNA supercoiling and remove chromosome
entanglements by catalyzing the ATP-dependent transport of one DNA duplex through
another. Type…
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