grant
Understanding and controlling protein energy landscapes by combining simulations and experiments
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AccountingActin-Activated ATPaseActin-S1 ATPaseActomyosin Subfragment 1 ATPaseAmazeAmino Acid SequenceBiological FunctionBiological ProcessBiologyBiophysicsCardiac DiseasesCardiac DisordersCardiac beta-MyosinComplexComputer SimulationComputer based SimulationDNA mutationDevelopmentDiseaseDisorderDrug DesignDrugsFamilyFoundationsFutureGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationHearingHeart DiseasesHeart failureHeavy Meromyosin Subfragment-1Machine LearningMedicationMotorMuscle Cell ContractionMuscle ContractionMuscular ContractionMutationMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosin S-1Myosin Subfragment-1Myosin V3MyosinsParasitic infectionPharmaceutical PreparationsPrimary Protein StructureProteinsSeriesStructureTestingVariantVariationVentricular Cardiac beta-MyosinVentricular beta-MyosinWorkbeta-Myosinbiophysical foundationbiophysical principlesbiophysical sciencescardiac failurecomputational simulationcomputerized simulationdesigndesigningdevelopmentaldrug discoverydrug-like chemicaldrug-like compounddrug-like moleculedrug/agentexperimentexperimental researchexperimental studyexperimentsgenome mutationheart disorderinfected with parasitesinsightmachine based learningmembermotor behaviormotor controlnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyparasite infectionprotein sequenceprotein structureprotein structuresproteins structurerational designsimulationsuccesstoolβ-Myosin
Description preview
Rational drug design and understanding of how mutations cause disease are largely based on the hypothesis
that a protein's sequence determines its structure, which determines its function. However, designing drugs and
interpreting new variants remain difficult, suggesting there is a missing factor in this sequence-structure-function
paradigm.…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click