grant
Uncovering the fundamental principles of transcriptional regulation
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 12 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026BacteriaBasal Transcription FactorBasal transcription factor genesBindingBinding SitesCell BodyCellsCodeCoding SystemCombining SiteComplexDNADNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDeoxyribonucleic AcidDiseaseDisorderE coliE. coliEscherichia coliGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenomeGoalsKnowledgeLibrariesMeasurementMeasuresModelingMolecular InteractionOrganismPatternPrevalenceProcessRNA ExpressionRNA PolymerasesReactive SiteRegulationSiteSpecific qualifier valueSpecifiedStimulusTestingTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional Regulationbiophysical modelcomputer based predictionempowermentgene manipulationgenetic manipulationgenetically manipulategenetically perturbinsightliving systemnew approachesnovel approachesnovel strategiesnovel strategypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpredictive modelingprogramspromoterpromotorresponsetheoriestranscription factor
Description preview
Project summary/Abstract
Cells are required to turn specific genes on, off, up or down in response to stimuli. Transcription factors (TFs) are
largely responsible for tuning (regulating) gene expression by binding to specific sites on DNA to interact with
(inhibit or enhance) the transcriptional machinery. While it is now possible to precisely…
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