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UNCOVERING THE COMBINED EFFECTS OF VEGFA AND ANG2 PRO-ANGIOGENIC SIGNALING IN HEREDITARY HEMORRHAGIC TELANGIECTASIA

Organization TULANE UNIVERSITY OF LOUISIANALocation NEW ORLEANS, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025Activin A Receptor Type II-Like 1Ang-2Ang2Angiopoietin-2AngiopoietinsAnti-VEGFAnti-VEGF Humanized Monoclonal AntibodyAnti-VEGF RhuMAbAntibodiesAortic AneurysmAppearanceArteriesArteriovenous AngiomaArteriovenous HemangiomaArteriovenous malformationAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBleedingBlood VesselsBody TissuesBone-Derived Transforming Growth FactorBrainBrain AVMsBrain Nervous SystemCD105CD105 AntigenCD105 GeneCancer ModelCancerModelCancersCell Communication and SignalingCell SignalingCerebral Arteriovenous MalformationsCerebrovascular systemCessation of lifeChronicClinicalColoring AgentsCommunicationConnective Tissue DiseasesConnective Tissue DisorderDNA mutationDPC4DeathDeleted in Pancreatic CarcinomaDevelopmentDiagnosisDiameterDiseaseDisorderDrosophila Homolog of Mothers Against Decapentaplegic 4DrugsDyesELISAEND GeneENG geneEffectivenessEncephalonEndoglinEndoglin GeneEnzyme-Linked Immunosorbent AssayEpistaxisExtravasationFDA approvedFLK1FrequenciesFutureGI PolypGastrointestinal PolypGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ChangeGenetic defectGenetic mutationGoalsHHT1HHT1 GeneHemorrhageHereditary hemorrhagic telangiectasiaHumanIndividualIntracellular Communication and SignalingJuvenile Multiple Polyps SyndromeJuvenile PolyposisJuvenile polyposis syndromeKDR geneKnowledgeLatexLeakageLifeLightLinkLiverLungLung Respiratory SystemMADH4MADH4 geneMalignant NeoplasmsMalignant TumorManuscriptsMedicationMentorshipMiceMice MammalsMicroscopyMilk Growth FactorMoAb VEGFModern ManMolecularMonoclonal Antibody Anti-VEGFMurineMusMutationNasal HemorrhageNeurofibrillary TanglesNose BleedNosebleedORW GeneORW1ORW1 GeneOperative ProceduresOperative Surgical ProceduresOrganOsler-Rendu DiseaseOsler-Weber-Rendu DiseasePathologicPathologyPatientsPharmaceutical PreparationsPhenotypePhotoradiationPlatelet Transforming Growth FactorPredispositionPrincipal InvestigatorProteomicsQOL improvementRacemose AngiomaRacemose HemangiomaReceptor ProteinRecombinant Humanized Anti-VEGF Monoclonal AntibodyRecombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth FactorReportingResearchResearch DesignResearch ResourcesResourcesRetinaRetinal Blood VesselsRetinal VesselsRhuMAb VEGFRoleSMA- and MAD-Related Protein 4SMAD4Serine/threonine-protein kinase Receptor R3 PrecursorSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpillageStaining methodStainsStudy TypeSurfaceSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTEK geneTGF BTGF-B Superfamily Receptor Type ITGF-betaTGF-βTGFbetaTGFβTIE-2TIE2TL1TNF Ligand-Related Molecule 1TNF15TNFSF15TNFSF15 geneTechnical ExpertiseTelangiectasiaTelangiectasisTestingTherapeuticTissuesTrainingTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor P Receptor IIITransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTumor Necrosis Factor Ligand Superfamily Member 15Type II-Like Kinase Activin A ReceptorUniversitiesVEGFVEGF ReceptorsVEGFAVEGFA geneVEGFRVEGFR-2VEGFR2VEGFsVEGIVMCMVMCM1VPF ReceptorVascular DiseasesVascular DisorderVascular Endothelial Cell Growth Factor ReceptorVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor 2Vascular Endothelial Growth FactorsVascular Endothelial Growth InhibitorVascular Permeability Factor ReceptorVasculotropinVeinsWritingactivin receptor-like kinase 1angiogenesisassess effectivenessbevacizumabbiological signal transductionblood lossblood vessel disorderblood vessels in the brainbrain arteriovenous malformationsbrain blood vesselsbrain vasculaturecerebral blood vesselcerebral vasculaturecerebrovascular vesselscerebrovasculatureconferenceconventiondensitydetermine effectivenessdevelopmentaldosagedrug/agenteffectiveness assessmenteffectiveness evaluationenzyme linked immunoassayevaluate effectivenessexamine effectivenessexperiencegenome mutationhepatic body systemhepatic organ systemimprovedimprovements in QOLimprovements in quality of lifeinhibitorinsightlow-frequency mutationmalformationmalignancymouse modelmurine modelneoplasm/cancerneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologypostnatalpre-clinical assessmentpreclinical assessmentpreventpreventingquality of life improvementrare allelerare mutationrare variantreceptorresearch studyretina blood vessel structureretinal vascular networkretinal vascular structureretinal vasculaturerhuMabVEGFsocial rolestudy designsummitsurgerysymposiasymposiumtangletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttechnical skillstherapeutically effectivetranscription factortranscriptomicsvascularvascular abnormalityvascular dysfunctionvasculopathy

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UNCOVERING THE COMBINED EFFECTS OF VEGFA AND ANG2 PRO-ANGIOGENIC SIGNALING IN HEREDITARY
HEMORRHAGIC TELANGIECTASIA
Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic vascular disease with no cure. HHT is
characterized by abnormalities in blood vessels that occur in mucocutaneous tissues (telangiectasias) and deep
tissues (arteriovenous…

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