grant
Uncovering dynamic brain circuit mechanisms associated with apathy and disinhibition in Alzheimer's Dementia
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AD and related dementiaAD dementiaAD pathologyAD related dementiaADRDAddressAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimers DementiaAmentiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAβBrainBrain Nervous SystemBrain imagingCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalComputer ModelsComputerized ModelsDataData SetDedicationsDementiaDepositDepositionDevelopmentDiagnosisDisease ProgressionDisinhibitionDistressDisturbance in cognitionDysfunctionElderlyEncephalonEnsureExhibitsFamilyFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderHealth Care SystemsHumanImpaired cognitionImpairmentIndividualIntervention StrategiesKnowledgeLifeLinkMT-bound tauMeasuresMediatingMental HealthMental HygieneMental disordersMental health disordersMetabolicModelingModern ManMotivationNervous System DiseasesNervous System DisorderNeurocognitiveNeurologic DisordersNeurological DisordersNeurosciencesNeurosciences ResearchPETPET ScanPET imagingPETSCANPETTParticipantPatientsPhysiopathologyPositive ValencePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProbabilistic ModelsProbabilityProbability ModelsPropertyPsychiatric DiseasePsychiatric DisorderPsychological HealthRDoCRad.-PETReportingReproducibilityResearchResearch Domain CriteriaRewardsRoleSeriesSocietiesStatistical ModelsSymptomsSystemTauopathiesTestingTraininga beta peptideaberrant agingabetaabeta accumulationabeta aggregationabnormal agingabnormal brain functionadvanced ageamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid β accumulationamyloid β aggregationamyloid-b proteinassociated symptomaβ accumulationaβ aggregationbeta amyloid fibrilbrain dysfunctionbrain impairmentbrain visualizationco-morbid symptomco-occuring symptomcognitive controlcognitive defectscognitive dysfunctioncognitive functioncognitive losscognitive neurosciencecomorbid symptomcomputational frameworkcomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputer frameworkcomputerized modelingconcurrent symptomcooccuring symptomdaily functioningdevelopmentaldiagnostic approachdiagnostic strategydysfunctional age related changedysfunctional agingdysfunctional brainexperiencefMRIgeriatrichealthy aginghealthy human agingimaging studyimpaired aginginsightlarge scale datalarge scale data setslarge scale datasetsmaladaptive agingmental illnessmicrotubule bound taumicrotubule-bound tauneuralneural imagingneuro-imagingneurobiological mechanismneuroimagingneurological diseaseneurological imagingneuropathologic tauneuropathological tauneuropsychiatric symptomnovelolder adultolder adulthoodpathological age related changespathological agingpathophysiologypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredictive modelingprimary degenerative dementiapsychiatric illnesspsychological disordersenile dementia of the Alzheimer typesenior citizensocial rolesoluble amyloid precursor proteinspatial and temporalspatial temporalspatiotemporalstatistical linear mixed modelsstatistical linear modelssymptom associationsymptom comorbiditytautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathyτ Proteins
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Project Summary
This project addresses the pressing and widespread challenges posed by Alzheimer's disease and related
dementias (ADRD), particularly the frequently co-occurring neuropsychiatric symptoms (NPS). ADRD are
prevalent, debilitating conditions that severely impair daily functioning and place a significant burden on
patients, families…
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