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Uncharted Territory: Mapping and Manipulating Cholinergic Basal Forebrain Activity in a Mouse Model of Alzheimer's Disease
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAccelerationAcetylcholineAcetylcholinesterase InhibitorsAffectAge MonthsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease patientAlzheimer's patientAlzheimers DementiaAmentiaAmyloid (Aβ) plaquesAmyloid PlaquesAnticholinesterase AgentsAnticholinesterase DrugsAnticholinesterasesAssayAttentionBehavioralBehavioral AssayBioassayBiological AssayBody TissuesBrainBrain MappingBrain Nervous SystemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCholinesterase InhibitorsCognitionCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive deficitsCognitive function abnormalControl GroupsDNA AlterationDNA Sequence AlterationDataDecision MakingDegenerative Neurologic DisordersDementiaDiseaseDisease ProgressionDisorderDisturbance in cognitionDrug TherapyEncephalonExhibitsFunctional MRIFunctional Magnetic Resonance ImagingGenetic AlterationGoalsHumanImageImpaired cognitionIntracellular Communication and SignalingInvestigationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMiceMice MammalsModern ManMolecularMolecular AnalysisMolecular FingerprintingMolecular ProfilingMurineMusNMR ImagingNMR TomographyNerve CellsNerve DegenerationNerve Impulse TransmissionNerve TransmissionNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuritic PlaquesNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationNeuronal TransmissionNeuronsNuclear Magnetic Resonance ImagingPathogenesisPathologicPathologyPatternPersonsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPrimary Senile Degenerative DementiaRNA-seq using translating ribosome affinity purificationResearchRoleSenile PlaquesSequence AlterationSignal TransductionSignal Transduction SystemsSignalingSourceSpecificitySubcellular ProcessSymptomsTRAP RNA sequencingTRAP RNA-seqTRAP-seqTherapeuticTissuesTransgenic MiceTranslating Ribosome Affinity Purification followed by RNA sequencingTranslating Ribosome Affinity Purification technology followed by RNA sequencingUnited StatesZeugmatographyacetylcholineesterase inhibitionacetylcholineesterase inhibitoralzheimer modelamyloid beta plaqueamyloid-b plaqueawakeaxon signalingaxon-glial signalingaxonal signalingaβ plaquesbasal forebrainbasal forebrain cholinergic neuronsbehavior outcomebehavioral outcomebiological signal transductionbrain cellcell typecellular targetingcholinergiccholinergic neuroncognitive defectscognitive dysfunctioncognitive functioncognitive losscored plaquedata modelingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdiffuse plaquedisease phenotypedrug interventiondrug treatmenteffective interventionexperimentexperimental researchexperimental studyexperimentsextracellularfMRIgene manipulationgenetic manipulationgenetically manipulategenetically perturbgenomic alterationglia signalingglial signalingglobal gene expressionglobal transcription profilehealthy aginghealthy human aginghyper-phosphorylated tauhyperphosphorylated tauimage-based methodimagingimaging methodimaging modalityimprove symptomimprovedin vivoinsightmodel of datamodel the datamodeling of the datamolecular profilemolecular signaturemouse modelmurine modelnerve signalingneural circuitneural circuitryneural degenerationneural signalingneurobehavioral symptomneurocircuitryneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological degenerationneuronalneuronal circuitneuronal circuitryneuronal degenerationneuronal signalingneurotransmissionoptogeneticspatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepharmaceuticalpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingprimary degenerative dementiasenile dementia of the Alzheimer typesocial rolespatial and temporalspatial temporalspatiotemporalsymptom improvementsymptomatic improvementsymptomatologysynaptic circuitsynaptic circuitrytangletherapeutic targettimelinetranscriptometranscriptomicstranslating ribosome affinity purification and RNA-sequencingtranslating ribosome affinity purification with RNA sequencing
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PROJECT SUMMARY
Alzheimer’s Disease (AD) is the most common form of dementia, affecting roughly 5.8 million people in the
United States. The most effective interventions for AD are pharmaceuticals that include acetylcholinesterase
inhibitors, which prevent the degradation of acetylcholine. While these treatments are capable of temporarily…
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