grant
Ultrafast Biophysical Studies of Biomolecules at the APS
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Active SitesAreaArticular Range of MotionBiochemicalBiochemical ReactionCell Communication and SignalingCell SignalingCodeCoding SystemCompensationComplementComplement ProteinsComputer softwareConventional X-RayCrystallizationCrystallographiesCrystallographyDataData SetDevicesDimensionsElectronsEnsureEnzymatic ReactionEnzyme GeneEnzymesEventExhibitsFiberFutureGoalsHealthHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHumanHybridsHydrogen OxideImageIndividualInfrastructureIntracellular Communication and SignalingInvestigatorsJoint Range of MotionJournalsLaser ElectromagneticLaser RadiationLasersLifeMagazineManuscriptsMeasuresMethodologyMethodsModern ManMolecular ConfigurationMolecular ConformationMolecular StereochemistryMotionNational Institutes of HealthNegative Beta ParticleNegatronsNoisePatternPhotonsPhysiologicPhysiologic pulsePhysiologicalPlayPropertyProteinsPulseResearchResearch PersonnelResearchersResolutionRoentgen RaysRoleRotationSamplingSideSignal TransductionSignal Transduction SystemsSignalingSiteSoftwareSourceSpecific qualifier valueSpecifiedSpottingsStandardizationStructureSynchrotronsTechnologyTemperatureTestingThumbThumb structureTimeTrainingUnited States National Institutes of HealthWaterWritingX-RadiationX-Ray ImagingX-Ray Medical ImagingX-Ray RadiationX-rayXrayXray free electron laserXray imagingXray medical imagingbeamlinebiological signal transductionbiophysical analysisbiophysical studieschemical reactioncomplementationconformationconformationalconformational stateconformationallyconformationsconventional Xraydata acquisitiondata acquisitionsdesigndesigningdetection limitdetection sensitivitydetectordrug developmentimage processingimagingimprovedinnovateinnovationinnovativeinsightkinematic modelkinematicsmacromoleculenew approachesnovel approachesnovel strategiesnovel strategyoperationoperationsrange of motionresolutionssocial rolestatisticssynchrotron radiationvirtualx-ray FELx-ray free-electron laser
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Our time-resolved x-ray studies of biomolecules have been pursued on the BioCARS beamline at the Advanced Photon Source (APS), which shut down operations in May 2023 to implement a major upgrade (APS-U) that aims to reduce significantly the horizontal emittance of electrons circulating in the synchrotron. This effort will allow x-rays generated…
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