UC Davis Comparative Oncology Training Program

Project Summary/Abstract
Preclinical animal models have been the foundation for the development of novel cancer therapies. Historically,
this foundation has relied on mouse models. While mouse models are fundamentally important, the models are
insufficient and need to be complemented. Companion animals are an important combination of outbred
animals that have spontaneous cancer development with an intact immune system and have environmental
and epigenetic exposures as humans. Tackling complex cancer research problems should include
investigators with broad experience across animal and human species presenting a unique opportunity for
DVMs and MDs to have a crucial role in basic to translational research. Veterinarians can strengthen
comparative approaches essential to multidisciplinary research accelerating innovative treatments for animals
and humans. Medical doctors bring a patient-centered approach linking biology with clinical therapy.
Unfortunately, recruiting and retaining biomedical scientists with comparative oncology expertise, especially
DVM or MD clinician-scientists, continues to be a challenging issue facing the broader research community.
The Comparative Oncology Training Program (T32) will provide an outstanding environment to train
predoctoral (DVM/PhD) students and post-DVM or post-MD fellows who are interested in cancer research. To
accomplish this goal, Drs. Chen, Kent, and Canter (MPIs) organized a diverse team of twenty-seven UC Davis
faculty mentors from the School of Veterinary Medicine, School of Medicine, College of Biological Science,
College of Agricultural and Environmental Sciences, and College of Engineering. The faculty mentors are
accomplished biomedical investigators with NCI or cancer-related funding. The proposed program will leverage
the NCI-designated UC Davis Comprehensive Cancer Center and will be fully integrated into the Center’s
cancer education program. The T32 program’s objectives are to: 1) recruit and retain a diverse group of
clinician-scientists that prepares them to become future leaders in academia, government service and public
health, 2) expose the T32 scholars to cancer-focused career paths, and 3) train the scholars to use
comparative medicine to address human cancer biology. The objectives will be accomplished by providing up
to 3-year funding support for DVM/PhD dual-degree predoctoral students and post-DVM or post-MD
postdoctoral fellows. During the training, the T32 scholars will enhance their knowledge through tailored
coursework, mentored research, multidisciplinary interactions, and career development activities. By the end
of the grant period, we expect to train eleven professionals encompassing two dual-degree DVM/PhD
students, seven post-DVM fellows, and two post-MD fellows to become highly-qualified basic and translational
comparative oncology researchers.

Grant Number: 5T32CA251007-05
NIH Institute/Center: NIH
Principal Investigator: Xinbin Chen