grant
UBIQUITIN-PROTEASOME PATHWAY in HUMAN DISEASE
Organization UNIVERSITY OF CONNECTICUT SCH OF MED/DNTLocation FARMINGTON, UNITED STATESPosted 1 Feb 2025Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1Active SitesAdoptedAffectAntioncogene Protein p53AssayBindingBioassayBiological AssayCancersCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell BodyCellsCellular Tumor Antigen P53ComplexDNA mutationDataDeubiquitinating EnzymeDevelopmentEnzyme GeneEnzymesFountain syndromeFutureGenesGenetic ChangeGenetic defectGenetic mutationGoalsHMG-20High Mobility Protein 20HumanHyperactivityLinkMacropainMacroxyproteinaseMalignant NeoplasmsMalignant TumorModern ManMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular Mechanisms of ActionMolecular StereochemistryMulticatalytic ProteinaseMutationNeurodevelopmental DisorderNeurological Development DisorderOncoprotein p53P53Pathway interactionsPatientsPhosphoprotein P53Phosphoprotein pp53ProsomeProteasomeProteasome Endopeptidase ComplexProtein TP53ProteinsProteomicsProteosomeRegulationRelaxationResearchRoleSEQ-ANSequence AnalysesSequence AnalysisSightSingle Crystal DiffractionStructureTP53TP53 geneTRP53Tumor Protein p53Tumor Protein p53 GeneUbiquitinViral DiseasesVirus DiseasesVisionWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyclinical relevanceclinically relevantconformationconformationalconformational stateconformationallyconformationsde-ubiquitinasede-ubiquitinating enzymedevelopmentalexperimentexperimental researchexperimental studyexperimentsgenome mutationhuman diseaseinsightmalignancymulticatalytic endopeptidase complexmutantneoplasm/cancerneurodevelopmental diseasenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachp53 Antigenp53 Genesp53 Tumor Suppressorpathwayprogramsprotein p53social roleubiquitin isopeptidaseubiquitin-specific isopeptidaseviral infectionvirus infectionvirus-induced diseasevisual function
Description preview
ABSTRACT
Ubiquitin-Proteasome Pathway (UPP) is a tightly regulated machinery that controls the degradation and turnover
of 80-90% of proteins in human cells. Its malfunction is linked to a plethora of human diseases, from
neurodevelopmental disorders and viral infections to cancer. The overarching goal of our research program is to
develop a…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click