grant
U Maryland Mid-Atlantic APOLLO Research Network Omic and Clinical Center
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 25 Sept 2017Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years oldAccelerationActive Follow-upAcuteAddressAfrican AmericanAfrican ancestryAfrican descentAfro AmericanAfroamericanAlbuminsAllograftingAmericanAntibodiesApolipoproteinsBacterial InfectionsBiopsyBloodBlood Reticuloendothelial SystemBlood SerumChildChild YouthChildren (0-21)ClassificationClinical DataConsentCost SavingsCounselingCreatinineDNADataDeoxyribonucleic AcidDisparitiesDisparityDonor personEducationEducational aspectsEnrollmentEnsureEnvironmental FactorEnvironmental Risk FactorEuropeanEvaluationFaceFailureGenesGeneticGenetic predisposing factorGenotypeGeographyGraft SurvivalHL-A AntigensHLA AntigensHealth Care CostsHealth CostsHospitalsHuman Leukocyte AntigensImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInvestigatorsKidneyKidney FailureKidney GraftingKidney InsufficiencyKidney TransplantationKidney TransplantsKidney Urinary SystemLesionLeukocyte AntigensLiving DonorsLong-term Follow-upMarylandMeasuresMedicalMedical centerMonitorNational Institutes of HealthOrganOutcomeOutcome StudyOutcomes ResearchParticipantPatternPhasePhenotypePoliciesPrevalenceProteinuriaQOLQuality of lifeRecurrent diseaseRegistriesRelapsed DiseaseRenal FailureRenal GraftingRenal InsufficiencyRenal TransplantationRenal TransplantsRenal functionReportingResearchResearch PersonnelResearchersRiskRisk-associated variantRoleSafetySerumSiteSlideSystematicsTimeTransplant RecipientsTransplantationUNOSUnited Network for Organ SharingUnited States National Institutes of HealthUniversitiesUrineVariantVariationViral DiseasesVirus DiseasesWashingtonactive followupbacteria infectionbacterial diseasebiobankbiorepositoryclinical centercohortdeceased donordeceased organ donorsdepositorydifferences due to racedifferences in racediffers by racediffers in racedigital pathologyenrollenvironmental riskethnic differenceethnicity differencefacesfacialfollow upfollow-upfollowed upfollowupgene interactiongenetic risk factorgraft failurehigh riskimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedindexinginherited factorkidney biopsykidney functionkidney txkidslive kidney donorliving kidney donorlong-term followupmedical collegemedical schoolsnovelpost-transplantpost-transplantationposthumous donorsposthumous organ donorposttransplantposttransplantationprimary outcomeprogramsprospectiverace based differencesrace differencesrace related differencesracial differenceracially differentrecruitrenalrenal biopsyrepositoryrisk allelerisk generisk genotyperisk locirisk locusrisk variantsafety assessmentschool of medicinesecondary outcomesocial roletransplanttransplant donortransplant patientviral infectionvirus infectionvirus-induced diseaseyoungster
Description preview
Project Summary
Relative to kidneys from European American (EA) deceased donors (DDs), kidneys transplanted from
African American (AA) DDs have significantly shorter graft survival. Several landmark studies revealed kidney
transplants from DDs with two apolipoprotein L1 gene (APOL1) risk variants, defining APOL1 high-risk
genotypes, have shorter…
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