grant
Type I Interferon induction of neuroinflammation mediates neuropsychiatric lupus
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 18 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025(IFN) α(IFN)-α(IFN)α7S Gamma GlobulinAD dementiaAddressAlferonAlpha-Beta-Omega Interferon Receptor-1Alzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmmon HornAntiviral Protein Alpha TypeAnxietyAstrocytesAstrocytusAstrogliaAutoantibodiesAutoimmune DiseasesBehaviorBlocking AntibodiesBlood CellsBlood SerumBody TissuesBrainBrain Nervous SystemCNS lupusCell BodyCell Communication and SignalingCell DensityCell SignalingCellsCentral Nervous System LupusCentral Nervous System Systemic Lupus ErythematosisCerebrospinal FluidCessation of lifeClinicalCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplementComplement ProteinsCornu AmmonisCutaneous DisorderDataDeathDefectDepositDepositionDermatosesDevelopmentDiseaseDisorderDisturbance in cognitionDrugsDysfunctionEncephalonEndotheliumFDA approvedFatigueFrequenciesFunctional disorderGene ExpressionGenesGliaGlial CellsHind BrainHippocampusHortega cellHuIFN-Alpha-RecIFNIFN AlphaIFN activationIFN αIFN-αIFNBRIFNaIFNαIFRCIgGImmunoglobulin GImpaired cognitionInfiltrationInflammationInflammatoryInjuryInterferon ActivationInterferon Alfa-n3Interferon Alpha-Beta Receptor Alpha ChainInterferon ReceptorInterferon Type IInterferon-αInterferonsIntracellular Communication and SignalingKidneyKidney DiseasesKidney Urinary SystemKnowledgeKolliker's reticulumLack of EnergyLeukocyte InterferonLinkLungLung Respiratory SystemLupusLupus Erythematosus DisseminatusLymphoblast InterferonLymphoblastoid InterferonLytotoxicityMacrophageMediatingMedicationMedulla SpinalisMeningesMental DepressionMiceMice MammalsMicrogliaModelingMouse StrainsMurineMusMφNephropathyNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurogliaNeuroglial CellsNeurologic DisordersNeurological DisordersNeuronsNeuropsychiatric LupusNeuropsychiatric SLENeuropsychiatric Systemic Lupus ErythematosusNon-neuronal cellNonneuronal cellPathogenicityPathway interactionsPatientsPeripheralPeripheral Blood CellPhagocytosisPharmaceutical PreparationsPhysiopathologyPrimary Senile Degenerative DementiaProcessProductionPsychosesRNA SeqRNA sequencingRNAseqReceptor SignalingRenal DiseaseReportingRhombencephalonRoleSLESLEB1 geneSchizophreniaSchizophrenic DisordersSeizuresSerumSignal TransductionSignal Transduction SystemsSignalingSiteSkinSkin DiseasesSkin Diseases and ManifestationsSourceSpinal CordSymptomsSynapsesSynapticSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTestingTissuesVascular Endothelial CellVascular EndotheliumWorkastrocytic gliaautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodybehavior changebehavior phenotypebehavioral phenotypingbiological signal transductionbrain parenchymacerebral spinal fluidcognitive dysfunctioncognitive losscomplementationcutaneous diseasecytokinecytotoxicitydementia praecoxdensitydepressiondermal diseasedermal disorderdevelopmentaldisseminated lupus erythematosusdrug/agentgene functiongene signaturesgenetic signaturegitter cellglial activationglial cell activationgray matterhindbrainhippocampalifnar1 gene productinjuriesinsightkidney disordermeningemesogliamicroglial cellmicrogliocytemouse modelmurine modelnerve cell deathnerve cell lossnerve cementneural inflammationneuroinflammationneuroinflammatoryneurological diseaseneuron cell deathneuron cell lossneuron deathneuron lossneuron toxicityneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal toxicityneuropsychiatric symptomneurotoxicneurotoxicitynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpathogenic autoantibodiespathophysiologypathwayperivascular glial cellpreventpreventingprimary degenerative dementiaprogramspsychiatric symptomrecruitrenalrenal disorderresponseschizophrenicself reactive antibodysenile dementia of the Alzheimer typeskin disordersle1social rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspinal fluidsubstantia griseasynapsesynaptic pruningsystemic lupus erythematosissystemic lupus erythematosus susceptibility 1transcriptome sequencingtranscriptomic sequencingtype I IFN receptortype I interferon receptor
Description preview
ABSTRACT:
In addition to peripheral symptoms such as skin and kidney disease, many Lupus patients (60-80%) also
develop psychiatric symptoms referred to as neuropsychiatric lupus (NPSLE). Recently, we reported an
interferon stimulated gene (ISG) signature in the CNS in a strain of lupus mice (Sle1 yaa) that correlated with a
behavior phenotype.…
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