grant
TTP and related proteins in the regulation of gene expression
Organization NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025(TNF)-α3' Untranslated Regions3'UTRAIDSAbscissionAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAnabolismArthritisAssayAtrophic ArthritisBindingBioassayBiochemicalBiological AssayC elegansC. elegansC.elegansCachectinCaenorhabditis elegansCancersCell BodyCell NucleusCellsCessation of lifeChronicComplexCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCytosolDeathDermatitisDictyosteliumDiseaseDisorderDrosophila melanogasterEGF-Response Factor 2ERF2ElementsEvaluationExcisionExtirpationFamilyFamily memberFission YeastG0-G1 switch regulatory protein 24GM-CSFGOS24 proteinGene Action RegulationGene Expression RegulationGene FamilyGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic PolymorphismGenetic TranscriptionGenomeGoalsGranulocyte-Macrophage Colony-Stimulating FactorGranulomatous EnteritisGrowth AgentsGrowth FactorGrowth SubstancesHealthHistamine-Producing Cell-Stimulating FactorHumanInflammationInflammatoryKO miceKnock-out MiceKnockout MiceL-SerineLeadMacrophageMacrophage-Derived TNFMalignant NeoplasmsMalignant TumorMediatingMedicalMessenger RNAMiceMice MammalsModern ManMolecular InteractionMolgramostinMonocyte-Derived TNFMouse Homolog of TIS11DMurineMusMφNIEHSNational Institute of Environmental Health SciencesNuP475 proteinNucleusNull MouseOrganismPathway interactionsPb elementPhenotypePhosphorylationPhysiologicPhysiologicalPoly(A) TailProcessProtein PhosphorylationProteinsProteins Growth FactorsRNA ExpressionRegulationRemovalRheumatoid ArthritisRodentRodentiaRodents MammalsS pombeS. pombeSchizosaccharomyces pombeSerineStimulusSurgical RemovalSyndromeTC-GM-CSFTIS11 proteinTIS11DTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTTP proteinTranscriptionTumor Necrosis FactorTumor Necrosis Factor-alphaTumor-Cell Human GM Colony-Stimulating FactorVariantVariationZFP36 proteinZFP36-Like 2ZFP36L2ZFP36L2 geneZinc Finger DomainZinc Finger MotifsZinc Finger Protein 36-Like 2Zinc Fingersarthriticbiosynthesisdrug developmenteleocolitisglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadinhibitorinsightliving systemmRNAmRNA DegradationmRNA Transcript Degradationmalignancymanmemberneoplasm/cancernew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathwaypolymorphismprototyperegional enteritisresectionresponserheumatic arthritisscreeningscreeningssmall moleculetranscriptometristetraprolinwasting
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Description preview
Tristetraprolin, or TTP, is the prototype of a small family of three CCCH tandem zinc finger proteins in man; other known human members of this class are ZFP36L1 and ZFP36L2, while rodents express an additional protein, ZFP36L3. TTP is the best studied member of this family. It is rapidly induced, translocated from the nucleus to the cytosol, and…
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